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Clinical utility of dual-energy CT used as an add-on to 18F FDG PET/CT in the preoperative staging of resectable NSCLC with suspected single osteolytic metastases.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wu Haijun[1,*1] * ; Dong Song[2] ; Li Xiuhui[3] ; Shi Lei[4] ; Shao Dan[5] ; Zhang Qing[5] ; Chen Min[6] ; Cao Yan[7] ; Thant Minn[7] ; Huang Xiaoyu[1] ;
机构： [1]Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [2]Department of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [3]Department of Information Media Industry, Guangzhou Public Utility Technician College, Guangzhou 510080, Guangdong, PR China [4]CT Collaboration, Simens Healthcare Ltd [5]Department of PET Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [6]Orthopedics of Traditional Chinese Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [7]Department of Radiology, Wayne State University/Detroit Medical Center, Detroit, MI, USA
出处：
DOI： 10.1016/j.lungcan.2019.10.032
ISSN：

关键词： Carcinoma Non-small-cell lung Neoplasm metastasis Positron emission tomography computed tomography Tomography X-ray computed Neoplasm staging

摘要：
To determine the clinical value of 18F-FDG-PET/CT and dual-energy virtual noncalcium CT to detect and identify single osteolytic metastases (SOM) in participants with non-small cell lung cancer (NSCLC). Forty-two participants (mean age, 63.5 years ± 10.1; range, 41-81 years) with suspected SOM diagnosed by whole-body 18F-FDG-PET/CT underwent non-enhanced dual-energy CT. All images were visually and quantitatively evaluated by two nuclear medicine physicians (R1 and R2) and two radiologists (R3 and R4) independently. The results of visual and quantitative analysis of 18F-FDG-PET/CT and dual-energy CT were compared with pathological results. In the visual analysis, the specificity and positive predictive value of dual-energy CT for reader 1 and reader 2 is larger than the corresponding figures of18F-FDG-PET/CT for reader 3 and reader 4 (94.1% each vs 82.4%/76.5%; 95.2%/95.0% vs 88.9%/86.2%). The sensitivity and negative predictive value of dual-energy CT is relatively lower than the number of 18F-FDG-PET/CT for readers (80.0%/76.0% vs 96.0%/100.0%; 76.2%/72.7% vs 93.3%/100.0%, respectively). ROI-based analysis of SUVmax on PET/CT images and CT numbers on VNCa images showed a significant difference between metastases and non-metastases (P < 0.001 each). Pre-surgical evaluation by combination of whole-body 18F-FDG-PET/CT and dual-energy CT could improve the classification of SOM and may further guide the surgical decision-making in participants with NSCLC. Copyright © 2019 Elsevier B.V. All rights reserved.

基金：
Natural Science Foundation of Guangdong Province (nos. 2017A020215192), and Guangzhou Science and Technology Project (CN) (nos. 201,804,010,049), and Guangdong Provincial People's Hospital "Dengfeng Plan" scientific research project (DFJH201912) P.R. China.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 呼吸系统 3 区 肿瘤学
最新[2025]版：
大类 | 2 区 医学
小类 | 3 区 肿瘤学 3 区 呼吸系统
JCR分区：
出版当年[2018]版：
Q1 RESPIRATORY SYSTEM Q2 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY Q1 RESPIRATORY SYSTEM

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [*1]Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, Guangdong, 510080, PR China
通讯作者：
通讯机构： [1]Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, PR China [*1]Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, Guangdong, 510080, PR China
推荐引用方式(GB/T 7714)：
Wu Haijun,Dong Song,Li Xiuhui,et al.Clinical utility of dual-energy CT used as an add-on to 18F FDG PET/CT in the preoperative staging of resectable NSCLC with suspected single osteolytic metastases.[J].LUNG CANCER.2020,140:80-86.doi:10.1016/j.lungcan.2019.10.032.
APA：
Wu Haijun,Dong Song,Li Xiuhui,Shi Lei,Shao Dan...&Huang Xiaoyu.(2020).Clinical utility of dual-energy CT used as an add-on to 18F FDG PET/CT in the preoperative staging of resectable NSCLC with suspected single osteolytic metastases..LUNG CANCER,140,
MLA：
Wu Haijun,et al."Clinical utility of dual-energy CT used as an add-on to 18F FDG PET/CT in the preoperative staging of resectable NSCLC with suspected single osteolytic metastases.".LUNG CANCER 140.(2020):80-86

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