Objectives: To assess the utility of Dual-layer spectral-detector CT (DLCT) in predicting the pT stage and histologic grade for colorectal adenocarcinoma (CRAC). Methods: A total of 131 patients (mean 62.7 +/- 12.9 years; 72 female, 59 male) with pathologically confirmed CRAC (35 pT1-2, 61 pT3, and 35 pT4; 32 high grade and 99 low grade), who received dual-phase DLCT were enrolled in this retrospective study. Normalized iodine concentration (NIC), slope of the spectral HU curve (lambda HU), and effective atomic number (Eff-Z) were measured for each lesion by two radiologists independently. Intraobserver reliability and interobserver agreement were assessed. The above values were compared between three pT-stage and two histologic-grade groups. The correlation between the pT stages and above values were assessed. Receiver operating characteristic (ROC) curves were calculated to evaluate the diagnostic efficacy. Results: Intra-class correlation coefficients were ranged from 0.856 to 0.983 for all measurements. Eff-Z [7.21(0.09) vs 7.31 (0.10) vs 7.35 (0.19)], NICAP [0.11 (0.05) vs 0.15 (0.08) vs 0.15 (0.08)), NICVP [0.27 (0.06) vs 0.34 (0.11) vs 0.35 (0.12)], lambda HUAP [1.20 (0.45) vs 1.93 (1.18) vs 2.37 (0.91)], and lambda HUVP [2.07 (0.68) vs 2.35 (0.62) vs 3.09 (1.07)] were significantly different among pT stage groups (all P<0.001) and exhibited a positive correlation with pT stages (r= 0.503, 0.455, 0.394, 0.512, 0.376, respectively, all P<0.001). Eff-Z [7.37 (0.10) vs 7.28 (0.08)1, NICAP [0.20 (0.10) vs 0.13 (0.08)), NICVP[0.35 (0.07) vs 0.31 (0.11)1, and lambda HUAP [2.59 (1.11) vs 1.63 (0.75)1 in the high-grade group were markedly higher than those in the low-grade group (all P<0.05). For discriminating the advanced- from early-stage CARC, the AUCs of Eff-Z, NICAP , NICVP, lambda HUAP , and lambda HUVP were 0.83, 0.80, 0.79, 0.86, and 0.68, respectively (all P<0.001). For discriminating the high- from low-grade CARC, the AUCs of Eff-Z, NICAP , NICVP, and lambda HUAP were 0.81, 0.81, 0.64, and 0.81, respectively (all P<0.05). Conclusions: The quantitative parameters derived from DLCT may provide new markers for assessing pT stages and histologic differentiation in patients with CRAC.
基金：
National Nature Science of Foundation of China; Youth Talent Project of The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; [82202259]; [ZY2022YL05]
第一作者机构：[1]Guangzhou Univ Chinese Med, Dept Radiol, Affiliated Hosp 2, Guangzhou, Peoples R China
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推荐引用方式(GB/T 7714)：
Chen Weicui,Ye Yongsong,Zhang Daochun,et al.Utility of dual-layer spectral-detector CT imaging for predicting pathological tumor stages and histologic grades of colorectal adenocarcinoma[J].FRONTIERS IN ONCOLOGY.2022,12:doi:10.3389/fonc.2022.1002592.
APA：
Chen, Weicui,Ye, Yongsong,Zhang, Daochun,Mao, Liting,Guo, Lei...&Liu, Xian.(2022).Utility of dual-layer spectral-detector CT imaging for predicting pathological tumor stages and histologic grades of colorectal adenocarcinoma.FRONTIERS IN ONCOLOGY,12,
MLA：
Chen, Weicui,et al."Utility of dual-layer spectral-detector CT imaging for predicting pathological tumor stages and histologic grades of colorectal adenocarcinoma".FRONTIERS IN ONCOLOGY 12.(2022)
