机构：[1]Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, 1 Xuefu North Road, Fuzhou 350122, Fujian, China[2]Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Provincial Universities and Colleges, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, Fujian, China[3]The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China[4]The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518107, Guangdong, China深圳医学信息中心中国医学科学院阜外医院深圳医院
Glioma is the most common type of primary brain tumor, and it has a high mortality rate. Currently, there are only a few therapeutic approaches for gliomas, and their effects are unsatisfactory. Therefore, uncovering the pathogenesis and exploring more therapeutic strategies for the treatment of gliomas are urgently needed to overcome the ongoing challenges. Cellular redox imbalance has been shown to be associated with the initiation and progression of gliomas. Among reactive oxygen species (ROS), hydrogen peroxide (H2O2) is considered the most suitable for redox signaling and is a potential candidate as a key molecule that determines the fate of cancer cells. In this review, we discuss the potential cellular and molecular roles of H2O2 in gliomagenesis and explore the potential implications of H2O2 in radiotherapy and chemotherapy and in the ongoing challenges of current glioma treatment. Moreover, we evaluate H2O2 as a potential redox sensor and potential driver molecule of nanocatalytic therapeutic strategies for glioma treatment.
基金：
the
Startup Fund for Scientific Research, Fujian Medical University
(2016QH004 and 2017XQ1003), Fujian Provincial Project of Education
and Science for Young and Middle-aged Teachers (JAT170211
and JAT170216), the National Natural Science Foundation of China
(81970993), the Natural Science Foundation of Fujian Province(2019J01297), the Medical Innovation Grant of Fujian Province (2019-
CX-36), and Fujian Medical University (XRCZX2017019).
第一作者机构：[1]Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, 1 Xuefu North Road, Fuzhou 350122, Fujian, China[2]Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Provincial Universities and Colleges, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, Fujian, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Ying,Wang Long,Wang Chaojia,et al.Potential implications of hydrogen peroxide in the pathogenesis and therapeutic strategies of gliomas.[J].ARCHIVES OF PHARMACAL RESEARCH.2020,43(2):187-203.doi:10.1007/s12272-020-01205-6.
APA：
Zhou Ying,Wang Long,Wang Chaojia,Wu Yilin,Chen Dongmei&Lee Tae Ho.(2020).Potential implications of hydrogen peroxide in the pathogenesis and therapeutic strategies of gliomas..ARCHIVES OF PHARMACAL RESEARCH,43,(2)
MLA：
Zhou Ying,et al."Potential implications of hydrogen peroxide in the pathogenesis and therapeutic strategies of gliomas.".ARCHIVES OF PHARMACAL RESEARCH 43..2(2020):187-203
