机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, China[2]The Marine Biomedical Research Institute, Southern Science and Engineering Guangdong Laboratory Zhanjiang, GuangdongMedical University, Zhanjiang 524023, China[3]Medical College of Georgia, Augusta University, Augusta, GA 30912, USA[4]First Affiliated Hospital, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China
With the length of about 26-31 nt, PIWI-interacting RNA (piRNA) is a small non-coding RNA (ncRNA) that interacts with PIWI proteins to form the piRNA silencing complex (piRISC). PIWI is a subfamily of Argonaute, and piRNA must bind to PIWI to exert its regulatory role. Current studies indicated that piRNA and PIWI are significantly abnormally expressed in gastric, breast, kidney, colon, and lung cancers, and are involved in the initiation, progression, and metastasis of cancers, which may be the potential diagnostic tools, prognostic markers, and therapeutic targets for cancers. By reviewing piRNA recent studies, this research summarized the mechanism of piRNA generation and the functions of piRNA/PIWI in gastric, breast, kidney, colon, and lung cancers, providing a reference value for further piRNA research.
基金：
This work was supported partly by National Natural Science
Foundation of China (81541153); Guangdong Provincial Science and
Technology Department (2016A050503046, 2015A050502048 and
2016B030309002); The Public Service Platform of South China Sea for
R&D Marine Biomedicine Resources (GDMUK201808); Southern
Marine Science and Engineering Guangdong Laboratory Zhanjiang
(ZJW-2019-07); Zhanjiang Science and technology Plan
(2017A06012); Research Project of “Excellent Innovative Talent
Support Program” of Heilongjiang University of Traditional Chinese
Medicine (2018RCD13); and “Group-type” Special Supporting Project
for Educational Talents in Universities (4SG19057G).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2025]版：
大类|2 区医学
小类|2 区肿瘤学
第一作者：
第一作者机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, China[2]The Marine Biomedical Research Institute, Southern Science and Engineering Guangdong Laboratory Zhanjiang, GuangdongMedical University, Zhanjiang 524023, China
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang 524023, China[2]The Marine Biomedical Research Institute, Southern Science and Engineering Guangdong Laboratory Zhanjiang, GuangdongMedical University, Zhanjiang 524023, China
推荐引用方式(GB/T 7714)：
Binghong Guo,Dongpei Li,Likun Du,et al.piRNAs: biogenesis and their potential roles in cancer.[J].Cancer metastasis reviews.2020,39(2):567-575.doi:10.1007/s10555-020-09863-0.
APA：
Binghong Guo,Dongpei Li,Likun Du&Xiao Zhu.(2020).piRNAs: biogenesis and their potential roles in cancer..Cancer metastasis reviews,39,(2)
MLA：
Binghong Guo,et al."piRNAs: biogenesis and their potential roles in cancer.".Cancer metastasis reviews 39..2(2020):567-575
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