机构：[1]Department of Traditional Chinese Medicine, Shenzhen Luohu People’s Hospital,Shenzhen, Guangdong, P.R. China深圳市康宁医院深圳市罗湖区人民医院深圳医学信息中心[2]Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China[3]Department of Traditional Chinese Medicine, The Third Affiliated Hospital ofShenzhen University, Shenzhen, Guangdong, P.R. China深圳市康宁医院深圳市罗湖区人民医院深圳医学信息中心[4]Department of Traditional Chinese Medicine, Shenzhen Luohu Hospital Group Luohu People’s Hospital, Shenzhen, Guangdong, P.R. China深圳市康宁医院深圳市罗湖区人民医院深圳医学信息中心[5]Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, P.R. China首都医科大学附属安贞医院[6]Capital Medical University, Beijing, P.R. China[7]Shantou University Medical College, Shantou University, Shantou, Guangdong,P.R. China[8]Department of Rehabilitation Medicine, Guangdong Geriatric Institute,Guangdong General Hospital and Guangdong Academy of Medical Sciences,Guangzhou, Guangdong, P.R. China广东省人民医院
BACKGROUND Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in diabetic patients. Shengmai Powder (SMP) was found to have cardioprotective effects. MATERIAL AND METHODS Based on the systematic pharmacological methodology, this research determined the genes of DCM and the known targets of SMP, predicted potential compounds and targets of SMP, constructed networks for DCM and SMP, and performed network analysis. RESULTS Five network were constructed: (1) the DCM gene PPI network; (2) the Compound-compound target network of SMP; (3) the SMP-DCM PPI network; (4) the Compound-known target network of SMP; (5) and the SMP known target-DCM PPI network. Several DCM and treatment related targets, clusters, signaling pathways, and biological processes were found. CONCLUSIONS SMP is able to regulate glycometabolism-related, lipid metabolism-related, inflammatory response-related, oxidative stress-related signaling pathways, and biological processes and targets, which suggests that SMP may have a therapeutic effect on DCM.
基金：
National Natural Science Foundation of China (No. 81603512 & No. 81874429), the postgraduate scientific research innovation project of Hunan Province of China (No. CX20190536, No. CX20190591, No. CX2018B465 and No. CX2017B428), Natural Science Foundation of Hunan Province of China (No. 2018JJ2289), Innovation project for graduate students of Hunan University of Chinese Medicine (No. 2018CX05 and No. 2018CX25), the postgraduate scientific research innovation project of Guangdong Yifang Pharmaceutical Co., Ltd. (No. yf201708), and the Digital Chinese medicine innovation research platform project (No. 49021001003005)
第一作者机构：[1]Department of Traditional Chinese Medicine, Shenzhen Luohu People’s Hospital,Shenzhen, Guangdong, P.R. China[2]Hunan University of Chinese Medicine, Changsha, Hunan, P.R. China[3]Department of Traditional Chinese Medicine, The Third Affiliated Hospital ofShenzhen University, Shenzhen, Guangdong, P.R. China[4]Department of Traditional Chinese Medicine, Shenzhen Luohu Hospital Group Luohu People’s Hospital, Shenzhen, Guangdong, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Traditional Chinese Medicine, Shenzhen Luohu People’s Hospital,Shenzhen, Guangdong, P.R. China[3]Department of Traditional Chinese Medicine, The Third Affiliated Hospital ofShenzhen University, Shenzhen, Guangdong, P.R. China[4]Department of Traditional Chinese Medicine, Shenzhen Luohu Hospital Group Luohu People’s Hospital, Shenzhen, Guangdong, P.R. China
推荐引用方式(GB/T 7714)：
Zhang Shi-Ying,Yang Kai-Lin,Long Zhi-Yong,et al.Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy.[J].MEDICAL SCIENCE MONITOR.2020,26:doi:10.12659/MSM.919029.
APA：
Zhang Shi-Ying,Yang Kai-Lin,Long Zhi-Yong,Li Wei-Qing&Huang Hui-Yong.(2020).Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy..MEDICAL SCIENCE MONITOR,26,
MLA：
Zhang Shi-Ying,et al."Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy.".MEDICAL SCIENCE MONITOR 26.(2020)
