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Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Mingtai[1,2] * ; Xie Ying[3] * ; Gong Shenglan[4] * ; Wang Yunqiao[1] * ; Yu Hao[1] * ; Zhou Tianran[5] ; Huang Furong[5] ; Guo Xin[1] ; Zhang Huanhuan[4] ; Huang Ruolan[6] ; Han Zhiyi[5] ; Xing Yufeng[1,5] ; Liu Qiang[2] ; Tong Guangdong[1,5,*1] ; Zhou Hua[1,7,*1] ;
机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China [2]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, PR China [3]School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, PR China [4]Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, PR China [5]Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, PR China [6]Department of Neurology, Shenzhen University Clinical Research Center for Neurological Diseases, Shenzhen University General Hospital, Shenzhen, PR China [7]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, Macau University of Science and Technology, Taipa, Macao, PR China
出处：
DOI： 10.1016/j.phrs.2021.105849
ISSN：

关键词： Nonalcoholic steatohepatitis Traditional Chinese medicine Lipid metabolism Inflammation Fibrosis Gut microbiota Review

摘要：
Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease in clinical practice. It has been considered that NASH is one of the main causes of chronic liver disease, cirrhosis and carcinoma. The mechanism of the NASH progression is complex, including lipid metabolism dysfunction, insulin resistance, oxidative stress, inflammation, apoptosis, fibrosis and gut microbiota dysbiosis. Except for lifestyle modification and bariatric surgery, there has been no pharmacological therapy that is being officially approved in NASH treatment. Traditional Chinese medicine (TCM), as a conventional and effective therapeutic strategy, has been proved to be beneficial in treating NASH in numbers of studies. In the light of this, TCM may provide a potential therapy for treating NASH. In this review, we summarized the associated mechanisms of action TCM treating NASH in preclinical studies and systematically analysis the effectiveness of TCM treating NASH in current clinical trials.Copyright © 2021. Published by Elsevier Ltd.

基金：
National Natural Science Foundation of China (grant number 81974558); National Natural Science Foundation of China (grant number 82104746); Sanming Project of Medicine in Shenzhen, Guangdong Province, China (grant numbers SZSM201612074, SZSM201612033); Shenzhen Municipal Scheme for Basic Research (JCYJ20190808144005614).
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2019]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China [2]Department of Cardiovascular Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China [5]Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, PR China [7]Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, Macau University of Science and Technology, Taipa, Macao, PR China [*1]Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, PR China.
推荐引用方式(GB/T 7714)：
Chen Mingtai,Xie Ying,Gong Shenglan,et al.Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis.[J].PHARMACOLOGICAL RESEARCH.2021,172:doi:10.1016/j.phrs.2021.105849.
APA：
Chen Mingtai,Xie Ying,Gong Shenglan,Wang Yunqiao,Yu Hao...&Zhou Hua.(2021).Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis..PHARMACOLOGICAL RESEARCH,172,
MLA：
Chen Mingtai,et al."Traditional Chinese medicine in the treatment of nonalcoholic steatohepatitis.".PHARMACOLOGICAL RESEARCH 172.(2021)

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