机构：[1]Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou 510080, People’s Republic of China[2]Pharmacy Department of Medical Supplies Center of General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, People’s Republic of China[3]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China
Post traumatic stress disorder (PTSD) is widely regarded as a stress-related and trauma disorder. The symptoms of PTSD are characterized as a spectrum of vulnerabilities after the exposure to an extremely traumatic stressor. Considering as one of complex mental disorders, little progress has been made toward its diagnostic biomarkers, despite the involvement of PTSD has been studied. Many studies into the underlying neurobiology of PTSD implicated the dysfunction of neurosteroids biosynthesis and neuorinflammatory processes. Translocator protein 18 kDa (TSPO) has been considered as one of the promising therapeutic biomarkers for neurological stress disorders (like PTSD, depression, anxiety, et al) without the benzodiazepine-like side effects. This protein participates in the formation of neurosteroids and modulation of neuroinflammation. The review outlines current knowledge involving the role of TSPO in the neuropathology of PTSD and the anti-PTSD-like effects of TSPO ligands.
基金：
Natural Science Foundation of Guangdong Province, China (No.
2017A030313448), National Natural Science Foundation of China (No.
81703731) and Educational Commission of Guangdong Province, China
(No. 2016KQNCX086).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|4 区内分泌学与代谢4 区神经科学
最新[2025]版：
大类|4 区医学
小类|4 区内分泌学与代谢4 区神经科学
第一作者：
第一作者机构：[1]Pharmaceutical Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Clinical Pharmacy Department of Guangdong Pharmaceutical University, Guangzhou 510080, People’s Republic of China
通讯作者：
推荐引用方式(GB/T 7714)：
Qiu Zhi-Kun,Liu Xu,Chen Yong,et al.Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder.[J].Metabolic brain disease.2020,35(5):695-707.doi:10.1007/s11011-020-00548-9.
APA：
Qiu Zhi-Kun,Liu Xu,Chen Yong,Wu Rong-Jia,Guan Shi-Feng...&Chen Ji-Sheng.(2020).Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder..Metabolic brain disease,35,(5)
MLA：
Qiu Zhi-Kun,et al."Translocator protein 18 kDa: a potential therapeutic biomarker for post traumatic stress disorder.".Metabolic brain disease 35..5(2020):695-707
