机构：[1]Department of Radiology, Jiangmen Central Hospital, Affiliated JiangmenHospital of Sun Yat-Sen University, No[23]Haibang Street, Jiangmen 529000,Guangdong, China[2]Department of Gastrointestinal Surgery, JiangmenCentral Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University,Jiangmen, Guangdong, China[3]Department of Pathology, Jiangmen CentralHospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University, Jiangmen,Guangdong, China[4]Department of Clinical Experimental Center, JiangmenCentral Hospital, Affiliated Jiangmen Hospital of Sun Yat-Sen University,Jiangmen, Guangdong, China[5]Department of Radiology, Foshan Hospital ofTraditional Chinese Medicine, Foshan, Guangdong, China
Lymphovascular invasion (LVI) has never been revealed by preoperative scans. It is necessary to use digital mammography in predicting LVI in patients with breast cancer preoperatively.
Overall 122 cases of invasive ductal carcinoma diagnosed between May 2017 and September 2018 were enrolled and assigned into the LVI positive group (n = 42) and the LVI negative group (n = 80). Independent t-test and χ2 test were performed.
Difference in Ki-67 between the two groups was statistically significant (P = 0.012). Differences in interstitial edema (P = 0.013) and skin thickening (P = 0.000) were statistically significant between the two groups. Multiple factor analysis showed that there were three independent risk factors for LVI: interstitial edema (odds ratio [OR] = 12.610; 95% confidence interval [CI]: 1.061-149.922; P = 0.045), blurring of subcutaneous fat (OR = 0.081; 95% CI: 0.012-0.645; P = 0.017) and skin thickening (OR = 9.041; 95% CI: 2.553-32.022; P = 0.001).
Interstitial edema, blurring of subcutaneous fat, and skin thickening are independent risk factors for LVI. The specificity of LVI prediction is as high as 98.8% when the three are used together.
基金：
National Natural Science Foundation of
China (Grant No. 81802918) and the Science and Technology Planning
Project of Jiangmen (Grant No. 2017A4016; Grant No. 2015068).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Department of Radiology, Jiangmen Central Hospital, Affiliated JiangmenHospital of Sun Yat-Sen University, No
共同第一作者：
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推荐引用方式(GB/T 7714)：
Liu Zhuangsheng,Li Ruqiong,Liang Keming,et al.Value of digital mammography in predicting lymphovascular invasion of breast cancer.[J].BMC cancer.2020,20(1):274.doi:10.1186/s12885-020-6712-z.
APA：
Liu Zhuangsheng,Li Ruqiong,Liang Keming,Chen Junhao,Chen Xiangmeng...&Long Wansheng.(2020).Value of digital mammography in predicting lymphovascular invasion of breast cancer..BMC cancer,20,(1)
MLA：
Liu Zhuangsheng,et al."Value of digital mammography in predicting lymphovascular invasion of breast cancer.".BMC cancer 20..1(2020):274
