机构：[1]Department of Urology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China[2]Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China[3]Shanghai TCM-Integrated Institute of Vascular Anomalies, Shanghai, China[4]Department of Laboratory Medicine, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China[5]Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong, China
Aim: Prostate cancer (PCa) is the sixth leading cause of cancer-related deaths in men throughout the world. This study aimed to investigate genes associated with the pathogenesis and prognosis of PCa. Materials & methods: Data of PCa cases were obtained from public datasets and were analyzed using an integrated bioinformatics strategy. Results: A total of 969 differential expression genes were identified. Moreover, GSE16560 and The Cancer Genome Atlas (TCGA) data showed a prognostic prompt function of the nine-gene signature, as well as in PCa with Gleason 7. Finally, majority of the nine hub genes were associated with drug sensitivity, mutational landscape, immune infiltrates and clinical characteristics of PCa. Conclusion: The nine-gene signature was correlated with drug sensitivity, mutational landscape, immune infiltrates, clinical characteristics and survival from PCa.
基金：
This work was supported by the grants from National Natural Science Foundation of China (no. 81601849), the Shanghai Natural
Science Foundation (17ZR1427600), National Science and Technology Major Projects for ′Major New Drugs Innovation and Development’
(2018ZX09201008-002-091), Shanghai Science and Technology Support Project in Biomedicine Field (18401932900),
Budgetary Projects of Shanghai University of Traditional Chinese Medicine (no. 2019LK046) and Special Clinical Research Project
of Health Profession of Shanghai Municipal Commission of Health (20194Y0081).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Urology, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
共同第一作者：
通讯作者：
通讯机构：[2]Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China[3]Shanghai TCM-Integrated Institute of Vascular Anomalies, Shanghai, China
推荐引用方式(GB/T 7714)：
Hai-Qi Mu,Zhi-Qiang Liang,Qi-Peng Xie,et al.Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer.[J].Biomarkers in medicine.2020,14(5):353-369.doi:10.2217/bmm-2019-0318.
APA：
Hai-Qi Mu,Zhi-Qiang Liang,Qi-Peng Xie,Wei Han,SenYang...&Jian Chen.(2020).Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer..Biomarkers in medicine,14,(5)
MLA：
Hai-Qi Mu,et al."Identification of potential crucial genes associated with the pathogenesis and prognosis of prostate cancer.".Biomarkers in medicine 14..5(2020):353-369
