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GanMeijian ameliorates lipid accumulation and oxidative damage in alcoholic fatty liver disease in Wistar rats.

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机构： [1]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China [2]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China [3]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai 200437, China [4]Department of Pharmacy, the First Naval Force Hospital of Southern Theatre Command, Zhanjiang 524005, Guangdong, China [5]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi'an 710032, Shaanxi, China [6]Xi'an Polytechnic University, No. 19 Jinhua South Road, Xi'an, Shaanxi 710048, China

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关键词： Phosphoesterase complex (Pho) Alcoholic fatty liver disease (AFLD) Oxidative stress

摘要：

Alcoholic fatty liver disease (AFLD), a major public health problem, has drawn clinical and scientific attention. The study aims to investigate the effect of Ganmeijian [crude extract of malt root, phosphoesterase complex (Pho)] on AFLD, and explore the possible mechanisms. An AFLD rat model was made. 30 and 60 mg/kg Pho were administrated through intestinal fistula for 5 weeks. Compared with those in model group, AST, LDL-C and TC in 30 mg/kg Pho group and TC in 60 mg/kg Pho group decreased. The mRNA level of Fas, Gpat1 and Srebp-1c in Pho groups was significantly reduced. The level of GSH-Px was increased, mitochondrial activity was improved, and the level of MDA and ROS was reduced in Pho groups. Pho shows a beneficial effect on AFLD. The mechanisms are possibly related to Pho inhibiting the expression of fat synthesis genes, protecting the function and increasing the activity of mitochondria in hepatocytes, then reducing the accumulation of ROS and the level of oxidative stress in the liver. Copyright © 2020 Elsevier Inc. All rights reserved.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区药学 3 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China [4]Department of Pharmacy, the First Naval Force Hospital of Southern Theatre Command, Zhanjiang 524005, Guangdong, China

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通讯作者：

通讯机构： [2]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437, China [3]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai 200437, China [*1]China State Institute of Pharmaceutical Industry, Shanghai Biological Substance Evaluation and Research Center, Shanghai 200040, China.

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GanMeijian ameliorates lipid accumulation and oxidative damage in alcoholic fatty liver disease in Wistar rats.

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