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Involvement of Hippocampal AMPA Receptors in Electroacupuncture Attenuating Depressive-Like Behaviors and Regulating Synaptic Proteins in Rats Subjected to Chronic Unpredictable Mild Stress.

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Jiang[1] * ; Hao Zhang[1] ; Junhe Zhou[1] ; Xiaorong Tang[2] ; Le Luo[2] ; Peidong Huang[2] ; Wei Yi[2] ; Nenggui Xu[2] ; Jianhua Liu[1] ; Wenbin Fu[1,*1] ;
机构： [1]Department of Acupuncture and Moxibustion, Guangdong Provinical Hospital of TCM, Guangzhou, 510120, China [2]Medical College of Acupuncture and Moxibustion, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China
出处：
DOI： 10.1016/j.wneu.2020.04.042
ISSN：

关键词： AMPA receptor electroacupuncture depression AMPAR antagonist

摘要：
A large body of evidence has suggested that the disruptions of neural plasticity in the brain play a pivotal role in major depressive disorder (MDD). Electroacupuncture (EA) therapy has been shown to be an effective treatment modality for MDD. However, the mechanism underling the antidepressive effect of EA treatment has not been clearly elucidated. This study aimed to investigate the antidepressant-like effects of EA associated with its protection effect of synaptic structural plasticity. An MDD model was induced by exposing Sprague Dawley rats to chronic unpredictable mild stress (CUMS). EA stimulation (Hegu and Taichong) and AMPA receptor (AMPAR) antagonist NBQX intrahippocampal injection were used to treat the depressed rats. We found EA improved behavioral performance, enhanced synaptic structural plasticity, and upregulated gene and protein levels of GluR1, GluR2, Stargazin, Pick1, SYP, PSD-95, and GAP-43. AMPAR antagonist NBQX had the opposite effect on behavioral performance, synaptic plasticity, and the aforementioned genes and proteins. These results suggest that EA has a potent antidepressant effect, likely through upregulated expression of the AMPAR and protected neural plasticity in CUMS-treated rats. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
National Nature Science Foundation of China (grant numbers 81403461 and 81173348).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 4 区 医学
小类 | 3 区 外科 4 区 临床神经病学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 外科
JCR分区：
出版当年[2018]版：
Q3 SURGERY Q4 CLINICAL NEUROLOGY
最新[2023]版：
Q2 SURGERY Q3 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Acupuncture and Moxibustion, Guangdong Provinical Hospital of TCM, Guangzhou, 510120, China
通讯作者：
通讯机构： [1]Department of Acupuncture and Moxibustion, Guangdong Provinical Hospital of TCM, Guangzhou, 510120, China [*1]Department of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, 111 Dade Road, Yuexiu District, Guangzhou, 510120, China
推荐引用方式(GB/T 7714)：
Li Jiang,Hao Zhang,Junhe Zhou,et al.Involvement of Hippocampal AMPA Receptors in Electroacupuncture Attenuating Depressive-Like Behaviors and Regulating Synaptic Proteins in Rats Subjected to Chronic Unpredictable Mild Stress.[J].WORLD NEUROSURGERY.2020,139:E455-E462.doi:10.1016/j.wneu.2020.04.042.
APA：
Li Jiang,Hao Zhang,Junhe Zhou,Xiaorong Tang,Le Luo...&Wenbin Fu.(2020).Involvement of Hippocampal AMPA Receptors in Electroacupuncture Attenuating Depressive-Like Behaviors and Regulating Synaptic Proteins in Rats Subjected to Chronic Unpredictable Mild Stress..WORLD NEUROSURGERY,139,
MLA：
Li Jiang,et al."Involvement of Hippocampal AMPA Receptors in Electroacupuncture Attenuating Depressive-Like Behaviors and Regulating Synaptic Proteins in Rats Subjected to Chronic Unpredictable Mild Stress.".WORLD NEUROSURGERY 139.(2020):E455-E462

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