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Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods

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收录情况： ◇ SCIE ◇ EI

作者：
Zihan Mei[a,b] * ; Duyang Gao[b] * ; Dehong Hu[b] ; Huichao Zhou[d] ; Teng Ma[b] ; Liang Huang[e] ; Xin Liu[b] ; Rongqin Zheng[d] ; Hairong Zheng[b] ; Ping Zhao[c] ; Jianqiao Zhou[a] ; Zonghai Sheng[b] ;
机构： [a]Department of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China [b]Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, CAS Key Laboratory of Health Informatics, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR China [c]Department of Ultrasound, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, 510405, PR China [d]Department of Medical Ultrasonic, Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, PR China [e]College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, PR China
出处：
DOI： 10.1016/j.biomaterials.2020.120092
ISSN：

关键词： Multidrug-resistant bacterial infections Near-infrared II Photoacoustic imaging Photothermal therapy Theranostics

摘要：
Multidrug-resistant Staphylococcus aureus (MRSA) seriously endanger human health. The development of efficient methods to eliminate the infections and monitor the treatment process are of great significance. Near-infrared-II (NIR-II) photoacoustic (PA) imaging and photothermal therapy (PTT) are highly integrated theranostic platforms with superior performance including a low imaging background, increased tissue penetration depth, and high photothermal threshold. Herein, we report an activatable near-infrared II (NIR-II) phototheranostic strategy using miniature Au/Ag nanorods (NRs) for the photochemical synergistic therapy of MRSA infections and in situ monitoring of the treatment progress. Au/Ag NRs were efficiently activated by ferricyanide solution and allowed to continuously release free Ag+ to eliminate MRSA, triggering NIR-II photothermal and PA performance enhancement. The activated NIR-II photothermal effect in turn accelerated the release of free Ag+ from Au/Ag NRs for the synergistic elimination of gram-positive Staphylococcus aureus and promoted wound healing. No photothermal damages or free Ag+-induced side effects were observed in treated mice. After synergistic treatment, a 20-fold NIR-II PA signal increase with a maximum signal-to-noise measurement of 9.5 was observed between the implanted site and normal tissue, enabling sensitive monitoring of Ag+ release process. The prepared Au/Ag NRs were stable and biocompatible, showing great potential for activatable NIR-II phototheranostic application. © 2020 Elsevier Ltd

基金：
This work was supported the National Key Research and Development Program of China : Scientific and Technological Innovation Cooperation of Mainland and Macao ( 2017YFE0120000 ), the Natural Science Foundation of China ( 91859117 , 81771906 , 81827807 , 81901812 , 81527901 , 21875218 ), CAS key laboratory of health informatics ( 2011DP173015 ), the Science and Technology Innovation Fund of Shenzhen ( JCYJ20170818161918918 , JCYJ20190812163614809 ), Shenzhen Key Laboratory of Ultrasound Imaging and Therapy ( ZDSYS201802061806314 ), High-Level University Construction Project ( A1-AFD018171Z11070 ), Research Fund for Young Teacher Training Project of Sun Yat-sen University ( 20ykpy42 ), and the China Postdoctoral Science Foundation ( 2019M653129 ).
语种：
外文
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中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 工程技术
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 工程：生物医学 1 区 材料科学：生物材料
JCR分区：
出版当年[2018]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [a]Department of Ultrasound, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, PR China [b]Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, CAS Key Laboratory of Health Informatics, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zihan Mei,Duyang Gao,Dehong Hu,et al.Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods[J].BIOMATERIALS.2020,251:doi:10.1016/j.biomaterials.2020.120092.
APA：
Zihan Mei,Duyang Gao,Dehong Hu,Huichao Zhou,Teng Ma...&Zonghai Sheng.(2020).Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods.BIOMATERIALS,251,
MLA：
Zihan Mei,et al."Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods".BIOMATERIALS 251.(2020)

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