Cardiovascular diseases are the main cause of mortality and morbidity worldwide. Cardiovascular diseases such as AMI, AS, cardiac hypertrophy and cardiac fibrosis can be alleviated by controlling the inflammatory response, cellular proliferation, production of ROS and secretion of cytokines. Sestrins are considered to be protective proteins which can prevent age-related diseases. A potential mechanism is an inhibitory effect on mTORC, which depends on the sestrin-AMPK-mTORC pathway. Sestrins regulate the M1/M2 macrophage balance, level of ROS and certain cytokines during stress and cardiovascular diseases through the above pathway. Sestrins exert different functions in diverse organs and tissue. According to existing studies, the main functions of sestrins are strongly associated with the pathological features of cardiovascular disease and exert protective roles in cardiovascular disease. Based on the current evidence, we present a mini-review on the physiological functions and mechanism of sestrins in cardiology. The purpose of this review is to summarize the functions and mechanism of sestrins in common cardiovascular diseases, to raise awareness in clinicians that sestrins may be an important potential target for controlling progression of disease. Copyright © 2020 Elsevier B.V. All rights reserved.