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Therapeutic potential of ALKB homologs for cardiovascular disease.

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机构： [1]Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China [2]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China [3]School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China [4]The Second Affiliated Hospital of Guangdong Pharmaceutical University, Yunfu, 527300, China

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关键词： Cardiovascular diseases ALKB homologs RNA demethylation DNA demethylation Oxidative stress Therapy

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Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation. These functions may regulate the physiological and pathological processes of CVDs, including inflammation, oxidative stress, cell apoptosis, and mitochondrial, endothelial, and fat metabolism dysfunction. In the present review, we summarize the biological functions of ALKB homologs and the relationship between the ALKB homologs and CVDs. Importantly, we discuss the roles of ALKB homologs in the regulation of oxidative stress, inflammation, autophagy, and DNA damage in CVDs, as well as the practical applications of ALKB homologs inhibitors or agonists in treating CVDs. In conclusion, the ALKBH family might be a promising target for CVDs therapy. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 3 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区医学：研究与实验 2 区药学

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第一作者机构： [1]Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China [2]School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China

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