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Deviating from clinical practice: Pharmacokinetics of Chinese materia medica faces a substantial challenge.

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机构: [1]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory and International Cooperation & Joint Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [3]Department of Traditional Chinese Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [4]The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou, China
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关键词: Pharmacokinetics of Chinese materia medica High-dosage administration Instrument sensitivity Target analyte Clinical practice Characteristics recognition

摘要:
The pharmacokinetics of Chinese materia medica (PCMM) has made a great contribution to investigations of the in vivo process of various components in Chinese materia medica (CMM), intending to provide useful information for clinical guidance related to CMM. However, some issues are worthy of further consideration, and current PCMM studies face a substantial challenge. First, high-dosage administration is prevalent in PCMM studies, and the obtained results might be meaningless and inappropriate for guiding the clinical application of CMM, as they deviate from clinical practice. Improvements in instrument sensitivity have not reduced the prevalence of high-dosage administration. In addition, the selection of components for detection in PCMM studies is usually uncertain, lacking sufficient scientific support, especially for components without clarified bioactivities. Therefore, the scientific value of current PCMM studies is limited. We believe that these abnormalities can be attributed to the poor recognition of the characteristics of CMM and the improper application of research approaches from Western medicines. Currently, the more pressing key scientific issues for CMM should be clinical effectiveness, quality control and bioactivity discovery, which are closely related to its own characteristics and are beneficial to its modern developments. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 医学:研究与实验 3 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 医学:研究与实验 2 区 药学
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出版当年[2018]版:
Q1 PHARMACOLOGY & PHARMACY Q2 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory and International Cooperation & Joint Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
通讯作者:
通讯机构: [1]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory and International Cooperation & Joint Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, China [*1]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
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