机构：[1]Department of Endocrine, Longhu People's Hospital, Shantou, Guangdong, China[2]Department of Emergency Intensive Care Unit(EICU), First Affiliated Hospital of Medical College of Shantou University, Dongxia S Rd, Jinping Qu, Shantou Shi, Guangdong Sheng, China[3]Department of Endocrine, Chao'an District People's Hospital, Chaozhou, Guangdong, China[4]Department of Pharmaceutics, Gomal University, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan[5]Department of Endocrinology, Shantou Traditional Chinese Medicine Hospital, Guangdong, China[6]Department of Endocrinology, Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China
Loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. To this end, we report that curcumin prevents high glucose (HG) induced oxidative stress and apoptosis in mouse pancreatic beta cells. Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1a and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK. Moreover, similar to curcumin, blockade of pERK1/2 reduced the HG induced apoptosis in pancreatic beta cells. Overexpression of CHOP or siRNA knockdown of PCG-1a counteracted the effect of curcumin on HG induced apoptosis and oxidative stress. These results suggest that curcumin acts through CHOP/PCG-1a and ERK1/2 signaling to block the HG induced oxidative stress and apoptosis.
基金：
Shantou science and technology project (No:180828094013938).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
无
最新[2025]版：
大类|4 区生物学
小类|4 区生化与分子生物学4 区细胞生物学
第一作者：
第一作者机构：[1]Department of Endocrine, Longhu People's Hospital, Shantou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[6]Department of Endocrinology, Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China[*1]Department of Endocrinology, Zhujiang Hospital Affiliated to Southern Medical University, Shantou, Guangdong, PR China
推荐引用方式(GB/T 7714)：
Hou Kaijian,Chen Yongru,Zhu Dan,et al.Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a and pERK1/2.[J].Frontiers in bioscience (Landmark edition).2020,25:1974-1984.doi:10.2741/4887.
APA：
Hou Kaijian,Chen Yongru,Zhu Dan,Chen Genben,Chen Fengwu...&Chen Rongping.(2020).Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a and pERK1/2..Frontiers in bioscience (Landmark edition),25,
MLA：
Hou Kaijian,et al."Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a and pERK1/2.".Frontiers in bioscience (Landmark edition) 25.(2020):1974-1984
