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Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation.

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机构： [1]Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [2]Department of Pharmacy, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [3]Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega institute), KU Leuven, Leuven, Belgium [4]Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [5]Department of Medical Ultrasonic, The Fifth Affiliated Hospital, University of SunYat-sen,Zhuhai,P. R. China

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关键词： humoral immunity IL-10 immunization marginal zone murine model regulatory B cells

摘要：

Artemisinin (ART) has been shown to suppress B cell activation and plasma cell formation. However, its effect on splenic marginal zone (MZ) B cells is unknown. Splenic MZ B cells play a critical role in rapidly induced Ab production against blood-borne foreign Ags. Dysfunction of MZ B cells, due to inhibition of its proliferation or displacement of its homing, results in an attenuated adaptive humoral response. Here, we investigate the effect of ART on splenic MZ B (CD19+ CD21high CD23low ) and B10 (CD19+ CD1dhigh CD5+ ) B cells to explore the mechanisms of ART-induced immunosuppression in T cell-deficient nude mice challenged with hamster xenoantigens. In this study, we demonstrate that ART decreases T cell-independent xenogeneic IgM Ab production and, this is associated with a strong suppression of MZ B cell proliferation and a relative increase of CD21low CD23+ follicular and B10 B cells. In addition, this suppression impairs IL-10 production. Taken together, our data indicate that ART suppresses B cell immune responses through a distinctive effect on splenic MZ B and other B cells. This represents a new mechanism of ART-induced immunosuppression. ©2020 Society for Leukocyte Biology.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区血液学 3 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区细胞生物学 4 区血液学 4 区免疫学

第一作者：

第一作者机构： [1]Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [5]Department of Medical Ultrasonic, The Fifth Affiliated Hospital, University of SunYat-sen,Zhuhai,P. R. China

通讯作者：

通讯机构： [1]Department of Traditional Chinese Medicine, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [4]Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, University of Sun Yat-sen, Zhuhai, P. R. China [*1]Department of Traditional Chinese Medicine, The FifthAffiliated Hospital, University of SunYat-sen,Meihuadong Road 52, Zhuhai, 519000,P. R. China

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