机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China[2]Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China[3]Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America[4]Department of pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America
Histo-blood group antigens (HBGAs) have been found to be important host susceptibility factors or receptors for human rotavirus (RVs) with genotype-specific host ranges, impacting the disease patterns, epidemiology, and strategy development against RV diseases in humans. However, how the glycan factors contribute to RV diversity and host ranges to different animal species remains unclear. In this study using recombinant VP8* proteins as probes to perform glycan array analyses of RVs, we observed a wide range of glycan binding profiles, including those binding to sialic acid containing glycans, among group A (RVA) and group C (RVC) RVs that mainly infect different animal species. A tri-saccharide glycan Galα1-3Galβ1-4Glc containing a terminal α-Gal was recognized by multiple RVA/RVC genotypes, providing valuable information on RV evolution under selection of the step-wisely synthesized HBGAs in many animals before they were introduced to humans to be human pathogens. Saliva binding studies of VP8* also revealed strain-specific host ranges or species barriers between humans and these animal RV genotypes, further improved our understanding on RV host ranges, disease burdens, epidemiology, and vaccine strategy against RVs.
基金：
NIH grants R21AI130631 and R56AI114831 to X. J. This study was also
supported by grants from the National Natural Science Foundation of China (81772243), the
Natural Science Foundation of Tianjin City (17JCYBJC42700) for Y. L.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区医学
小类|2 区免疫学2 区微生物学
最新[2025]版：
大类|1 区医学
小类|1 区传染病学1 区微生物学2 区免疫学
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China[2]Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China[3]Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America[4]Department of pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America[*1]Division of Infectious Diseases Cincinnati Children’s Hospital Medical Center 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA[*2]School of Traditional Chinese Medicine, Southern Medical University 1838 North Guangzhou Avenue, Guangzhou, Guangdong, China[*3]Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
推荐引用方式(GB/T 7714)：
Zhao Dandan,Liu Yang,Huang Pengwei,et al.Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species.[J].Emerging microbes & infections.2020,9(1):1609-1617.doi:10.1080/22221751.2020.1782270.
APA：
Zhao Dandan,Liu Yang,Huang Pengwei,Xia Ming,Li Weiwei...&Jiang Xi.(2020).Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species..Emerging microbes & infections,9,(1)
MLA：
Zhao Dandan,et al."Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species.".Emerging microbes & infections 9..1(2020):1609-1617
医学