机构：[1]Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China[2]The First Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, China[3]Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China[4]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China[5]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China[6]Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, China[7]Changchun University of Traditional Chinese Medicine, Changchun, Jilin, China[8]Shanxi University of Traditional Chinese Medicine, Xianyang, Shanxi, China[9]Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China[10]Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
Diarrhea-predominant irritable bowel syndrome (IBS-D) and functional diarrhea (FD) are highly prevalent, and the effectiveness of acupuncture for managing IBS-D and FD is still unknown.The aim of this study was to compare the effectiveness of electroacupuncture with loperamide.It was a prospective, randomized, parallel group controlled trial.A total of 448 participants were randomly assigned to He electroacupuncture group (n = 113), Shu-Mu electroacupuncture group (n = 111), He-Shu-Mu electroacupuncture group (n = 112), or loperamide group (n = 112). Participants in the 3 acupuncture groups received 16 sessions of electroacupuncture during a 4-week treatment phase, whereas participants in the loperamide group received oral loperamide 2 mg thrice daily. The primary outcome was the change from baseline in stool frequency at the end of the 4-weeks treatment. The secondary outcomes were the Bristol scale, the MOS 36-item short form health survey (SF-36), the weekly average number of days with normal defecations and the proportion of adverse events.Stool frequency was significantly reduced at the end of the 4-week treatment in the 4 groups (mean change from baseline, 5.35 times/week). No significant difference was found between the 3 electroacupuncture groups and the loperamide group in the primary outcome (He vs. loperamide group [mean difference 0.6, 95% CI, -1.2 to 2.4]; Shu-Mu vs. loperamide group [0.4, 95% CI, -1.4 to 2.3]; He-Shu-Mu vs. loperamide group [0.0, 95% CI, -1.8 to 1.8]). Both electroacupuncture and loperamide significantly improved the mean score of Bristol scale and increased the weekly average number of days with normal defecations and the mean scores of SF-36; they were equivalent in these outcomes. However, the participants in electroacupuncture groups did not report fewer adverse events than those in the loperamide group. Similar results were found in a subgroup analysis of separating patients with IBS-D and FD patients.Electroacupuncture is equivalent to loperamide for reducing stool frequency in IBS-D and FD patients. Further studies on cost effectiveness of acupuncture are warranted.
基金：
National Basic Research Program of China (973 Program, no. 2011CB505200).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|2 区医学
小类|2 区医学：内科
最新[2025]版：
大类|4 区医学
小类|4 区医学：内科
第一作者：
第一作者机构：[1]Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
共同第一作者：
通讯作者：
通讯机构：[4]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China[5]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China[*1]Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China[*2]Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Zheng Hui,Li Ying,Zhang Wei,et al.Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial.[J].Medicine.2016,95(24):e3884.doi:10.1097/MD.0000000000003884.
APA：
Zheng Hui,Li Ying,Zhang Wei,Zeng Fang,Zhou Si-Yuan...&Zhu Bing.(2016).Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial..Medicine,95,(24)
MLA：
Zheng Hui,et al."Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial.".Medicine 95..24(2016):e3884
