个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis.

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Zhang Yuping[1] * ; Chen Yonger[2] * ; Li Baixue[1] ; Ding Ping[2] ; Jin Daxiang[3] ; Hou Shaozhen[2] ; Cai Xiaochun[4] ; Sheng Xiujie[1,*1] ;
机构： [1]Department of Gynaecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China [2]School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong, China [3]Department of Osteology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, China [4]Department of Gynecology and Obstetrics, Chenghai District People’s Hospital, Shantou, 515800, Guangdong, China
出处：
DOI： 10.1016/j.biopha.2020.110408
ISSN：

关键词： Monotropein Acute kidney injury Oxidative stress Inflammation Apoptosis

摘要：
Although cisplatin is a common drug in the treatment of malignant tumors, its clinical application is limited due to various side effects, especially acute kidney injury (AKI). Till now, few effective pharmacological strategies can be applied to inhibit cisplatin-induced AKI. Here, we aimed to investigate the protective effects and possible mechanisms of monotropein on cisplatin-induced AKI. In this study, an AKI model was established in cisplatin-treated mice, and serum level of inflammatory cytokines, protein expressions of biochemical indicators and renal pathology were analyzed. Our results showed that our results showed that monotropein could significantly attenuate cisplatin-induced nephrotoxicity and reduce the levels of blood urea nitrogen (BUN) and serum creatinine (CRE). Furthermore, monotropein inhibited cisplatin-induced oxidative stress by reducing MDA level and increasing the activities of GSH, SOD and CAT. The underlying mechanisms of monotropein on alleviating cisplatin-induced AKI were associated with the activation of Nrf2/HO-1 pathway against oxidative stress and the inhibition on NF-κB signaling to suppress inflammation as well as the regulation on the expressions of proteins in apoptosis pathway in this renal injury model. This study firstly provided the evidence that monotropein could significantly attenuate cisplatin-induced AKI and suggested that monotropein might be used as a potential agent to alleviate side effects of cisplatin. Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

基金：
Science and Technology Planning Project of Guangdong Province China (2014A020212517, 2016A020226007); Science and Technology Planning Project of Guangzhou City China (201607010169); National Key R&D Program of China (2017YFC1701104); the Science and Technology Project Scheme of Guangdong Province China (No. 2015B020234008).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 药学
第一作者：
第一作者机构： [1]Department of Gynaecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Gynaecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, Guangdong, China [*1]Department of Gynaecology, The Third Affiliated Hospital of Guangzhou Medical University, Liwan District, Duobao Road 63, Guangzhou, Guangdong, 510000, China
推荐引用方式(GB/T 7714)：
Zhang Yuping,Chen Yonger,Li Baixue,et al.The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis.[J].BIOMEDICINE & PHARMACOTHERAPY.2020,129:110408.doi:10.1016/j.biopha.2020.110408.
APA：
Zhang Yuping,Chen Yonger,Li Baixue,Ding Ping,Jin Daxiang...&Sheng Xiujie.(2020).The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis..BIOMEDICINE & PHARMACOTHERAPY,129,
MLA：
Zhang Yuping,et al."The effect of monotropein on alleviating cisplatin-induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis.".BIOMEDICINE & PHARMACOTHERAPY 129.(2020):110408

相关文献

[1]Dihydroartemisinin attenuates lipopolysaccharide-induced acute kidney injury by inhibiting inflammation and oxidative stress. [2]Huangqi-Danshen decoction protects against cisplatin-induced acute kidney injury in mice [3]Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects [4]Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway [5]Arachidonic acid metabolism as a therapeutic target in AKI-to-CKD transition [6]Andrographolide contributes to spinal cord injury repair via inhibition of apoptosis, oxidative stress and inflammation [7]Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway [8]Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis. [9]Mogroside IIIE Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Podocytes by the Activation of AMPK/SIRT1 Signaling Pathway. [10]A Chinese Medicine Compound Alleviates Cisplatin-Induced Acute Kidney Injury via Its Antiapoptosis and Anti-Inflammation Effects in Mice

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号