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Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway.

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机构： [1]Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China [2]Department of Orthopedic Sursery, West China Hospital, Chengdu, Sichuan, China [3]Southern Medical Science Ltd, Kaohsiung, Taiwan ROC [4]School of Basic Medical Sciences of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

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关键词： ADSC collagen hypertrophic scars myofibroblasts p38/MAPK pathway α‐SMA

摘要：

The current study was designed to investigate the effects and underlying mechanisms of adipose tissue-derived stem cells (ADSCs) on hypertrophic scar (HS) fibrosis. Real-time quantitative polymerase chain reaction (qRT-PCR) and Western blot analysis were performed to detect the expression of collagen I (Col1), collagen III (Col3), and α-smooth muscle actin (α-SMA) after fibroblasts and cultured HS tissues were treated with ADSC medium. All data were analyzed by using SPSS17.0 software. Statistical analysis was performed by Student t tests. The in vitro study showed that ADSC medium decreased the expression of Col1, Col3, and α-SMA. In addition, the protein level of p-p38 was downregulated by ADSC medium treatment in a concentration dependent manner. The current study demonstrated that ADSC could decrease collagen deposition and scar formation in in vitro experiments. The regulation of the p38/MAPK signaling pathway might play an important role in the process. © 2018 Wiley Periodicals, Inc.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

第一作者：

第一作者机构： [1]Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China

通讯作者：

通讯机构： [1]Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China [*1]Department of Breast and Thyroid Surgery, Reniminl Hospital of Wuhan University, No 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei, China.

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