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Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components.

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资源类型：
Pubmed体系：
作者：
Song Zhuoyue[1] * ; Li Hailun[3] * ; Liang Jian[1] * ; Xu Yingtao[4] ; Zhu Lijun[1] ; Ye Xianying[1] ; Wu Jun[4] ; Li Wei[1] ; Xiong Qingping[1,2] ; Li Shijie[1] ;
机构： [1]School of Pharmaceutical Science, Mathematical Engineering Academy of ChineseMedicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]Jiangsu Provincial Key Laboratory of Palygorskite Science and Applied Technology, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China [3]Department of Geriatric Medicine, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, PR China [4]School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai 264199, Shangdong, PR China
出处：
DOI： 10.1016/j.ijbiomac.2019.08.173
ISSN：

关键词： Sulfated polysaccharide from Undaria pinnatifida Atherosclerosis plaques Stabilization

摘要：
The purpose of this study was to investigate the stable effect and mechanism of sulfated polysaccharide from Undaria pinnatifida (SPUP) on atherosclerotic plaque. The results showed that atherosclerotic plaques in the ApoE-/- mice of high-fat diet model group increased significantly without drug intervention. The content of vulnerable components (lipid, inflammatory macrophage) increased significantly, and the content of stability components (smooth muscle cell, collagen) reduced significantly. However, it could find that atherosclerotic plaque areas were decreased in a dose-dependent manner after SPUP intervention. SPUP could enhance the dominance of the stability components in plaque, and reduce the content of vulnerable component. Furthermore, SPUP could significantly reduce the matrix metalloprotein-9 content in atherosclerotic plaque. These results suggested that SPUP could stabilize atherosclerotic plaque by enhancing the dominance of the stability components content, reducing the vulnerability components content, and lowering the vulnerability index value. Copyright © 2019 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (No. 81803865, 81503387), Qing Lan Project of Jiangsu Province, Six Talent Peaks Project in Jiangsu Province (2017- YY-003), Open Funds of Jiangsu Provincial Key Laboratory of Palygorskite Science and Applied Technology (HPK201704), Open fund of Guangdong Provincial Key Laboratory of NewDrug Development and Research of Chinese Medicine (2017B030314096-02).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 生物
小类 | 2 区 应用化学 2 区 高分子科学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
第一作者：
第一作者机构： [1]School of Pharmaceutical Science, Mathematical Engineering Academy of ChineseMedicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
共同第一作者：
通讯作者：
通讯机构： [1]School of Pharmaceutical Science, Mathematical Engineering Academy of ChineseMedicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]Jiangsu Provincial Key Laboratory of Palygorskite Science and Applied Technology, Huaiyin Institute of Technology, Huai'an 223003, Jiangsu, PR China
推荐引用方式(GB/T 7714)：
Song Zhuoyue,Li Hailun,Liang Jian,et al.Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components.[J].International journal of biological macromolecules.2019,140:621-630.doi:10.1016/j.ijbiomac.2019.08.173.
APA：
Song Zhuoyue,Li Hailun,Liang Jian,Xu Yingtao,Zhu Lijun...&Li Shijie.(2019).Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components..International journal of biological macromolecules,140,
MLA：
Song Zhuoyue,et al."Sulfated polysaccharide from Undaria pinnatifida stabilizes the atherosclerotic plaque via enhancing the dominance of the stabilizing components.".International journal of biological macromolecules 140.(2019):621-630

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