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Metabolic profiles and pharmacokinetics of Qingre Xiaoyanning capsule, a traditional Chinese medicine prescription of Sarcandrae Herba, in rats by UHPLC coupled with quadrupole time-of-flight tandem mass spectrometry.

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机构： [1]College of Pharmacy, Jinan University, Guangzhou, P. R. China. [2]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China. [3]Department of Pharmacy, First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.

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关键词： metabolic profiles pharmacokinetics Sarcandrae Herba semi-quantification traditional Chinese medicine

摘要：

Qingre Xiaoyanning capsule is a famous traditional Chinese medicine prescription which consisted of Sarcandrae Herba (also named Caoshanhu in China) water extract for the frequent treatment of inflammation and immunity related diseases. Until now, the in vivo bioactive components of Qingre Xiaoyanning capsule have not yet been fully addressed. In this study, a total of 42 xenobiotics including 20 prototypes and 22 metabolites were identified in rats after oral administration of Qingre Xiaoyanning capsule using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. Subsequently, isofraxidin and rosmarinic acid, two bioactive components with high exposure in rat plasma, were quantitatively analyzed, while another 20 major absorbed components were semi-quantitatively measured, to investigate together the pharmacokinetics behavior of Qingre Xiaoyanning capsule. Taken together, this study provided comprehensive knowledge of in vivo disposal of this prescription, which could help reveal the potential bioactive components, and would be conducive to further pharmacological mechanism research as well as quality control approach improvement of Qingre Xiaoyanning capsule and Sarcandrae Herba related prescriptions. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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出版当年[2018]版：

大类 | 3 区化学

小类 | 3 区分析化学

最新[2025]版：

大类 | 3 区工程技术

小类 | 3 区分析化学

第一作者：

第一作者机构： [1]College of Pharmacy, Jinan University, Guangzhou, P. R. China. [2]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China.

通讯作者：

通讯机构： [1]College of Pharmacy, Jinan University, Guangzhou, P. R. China. [2]Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China. [*1]College of Pharmacy, JinanUniversity,Guangzhou 510632, P. R. China.

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