机构：[1]Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, China.[2]Department of Dermatovenereology, Foshan Maternal and Child Health Hospital, Foshan, Guangdong 528000, China.[3]Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510315, China.[4]Department of Gynecology, The Fisrt People's Hospital of Huizhou City, Huizhou, Guangdong 516000, China.[5]Department of Gynecology Oncology, The Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510000, China.[6]Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.
To investigate TCF4 expression in epithelial ovarian cancer, and to explore its correlation with clinicopathological parameters and clinical prognosis of epithelial ovarian cancer.
From 2009 to 2017, 188 cases of paraffin-embedded epithelial ovarian cancer tissues and 41 paratumor ovarian tissues which had been confirmed at the memorial hospital of Sun Yat-sen University were collected in this study, and the expression of TCF4 was performed by immunohistochemistry using a polyclonal antibody specific for TCF4.
The expression of TCF4 protein was associated with disease progression free survival and overall survival in epithelial ovarian cancer patients; and TCF4 overexpression was associated with age, FIGO stage, lymph node metastasis, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence, and serum CA153. Moreover, in a multivariate Cox regression analysis TCF4 overexpression was an indeed independent prognostic factor in epithelial ovarian cancer.
TCF4 may play an oncogenic role in epithelial ovarian cancer, and TCF4 is a useful independent prognostic biomarker of epithelial ovarian cancer, and it may provide a candidate target therapy treatment in future.
基金：
This work was supported by the Nature Science Fund of Guangdong Province (no.2016A030313536).
第一作者机构：[1]Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, China.
共同第一作者：
通讯作者：
通讯机构：[3]Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, 510315, China.[6]Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China.[*1]Cancer Center, Southern Medical University, Guangzhou, Guangdong 510315, China.[*2]Department of Gynecology Oncology, The Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, China
推荐引用方式(GB/T 7714)：
Liu Longyang,Zeng Zhaoyang,Yi Juanjuan,et al.Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer.[J].CANCER BIOMARKERS.2019,24(2):213-221.doi:10.3233/CBM-181849.
APA：
Liu Longyang,Zeng Zhaoyang,Yi Juanjuan,Zuo Liu,Lv Jin...&Feng Xin.(2019).Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer..CANCER BIOMARKERS,24,(2)
MLA：
Liu Longyang,et al."Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer.".CANCER BIOMARKERS 24..2(2019):213-221
