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Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.

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收录情况： ◇ SCIE

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机构： [1]Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, Hebei, China [2]Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shenzhen PKU‑HKUST Medical Center, Shenzhen, 518036, Guangdong, China [3]Department of Nursing, Hebei University of Chinese Medicine, Shijiazhuang, 050020, Hebei, China [4]No.1 Middle School of Yuxian, Yuxian, 075700, Hebei, China [5]Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China

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关键词： Erythropoietin Hypoxia-inducible factor HIF-2α Histone demethylase JMJD1A

摘要：

Erythropoietin (EPO) is a secreted hormone that stimulates the production of red blood cells, and the level of EPO is increased under hypoxia. The expression of EPO is regulated not only by the hypoxia-inducible factor (HIF) but also partly through epigenetic modifications, including histone acetylation and methylation. In this study, we report that histone H3K9 demethylase JMJD1 A is regulated by HIF-2α in HepG2 cells under hypoxia. Knockdown or over-expression of JMJD1 A can decrease or increase EPO expression, respectively. JMJD1 A can interact with HIF-2α to form a co-activator complex, which binds to the hypoxia response elements of EPO and increases EPO expression by catalyzing demethylation of H3K9me2, a transcription suppression marker. The results demonstrate that JMJD1 A is a co-activator of EPO expression. Copyright © 2019. Published by Elsevier Ltd.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 3 区生化与分子生物学 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2017]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.4 最新[2023版] 4.3 最新五年平均 3.247 出版当年[2017版] 3.813 出版当年五年平均 3.505 出版前一年[2016版] 3.144 出版后一年[2018版]

第一作者：

第一作者机构： [1]Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, Hebei, China [4]No.1 Middle School of Yuxian, Yuxian, 075700, Hebei, China

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通讯作者：

通讯机构： [1]Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, Hebei, China [2]Department of Urology, Peking University Shenzhen Hospital, Institute of Urology of Shenzhen PKU‑HKUST Medical Center, Shenzhen, 518036, Guangdong, China [*1]Peking University Shenzhen Hospital, No 1120, Lianhua Road, Shenzhen, 518036, China [*2]College of Life Science, Hebei Normal University, No 20 Nanerhuan East Road, Shijiazhuang, 050024, China

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Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.

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