个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modulating immune homeostasis in mice.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yang Y Q[1] * ; Wu Y F[2] * ; Xu F F[1,3] ; Deng J B[1] ; Wu L L[1] ; Han X D[1,3] ; Liang J[2] ; Guo D A[1,4] ; Liu B[1,3] ;
机构： [1]The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China [2]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China [3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China [4]Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China
出处：
DOI： 10.1016/j.phymed.2019.152855
ISSN：

关键词： Tripterygium wilfordii Hook F Inflammatory bowel disease apoptosis DSS T lymphocytes

摘要：
The Tripterygium glycosides (TG) is the main active extractive of Tripterygium wilfordii Hook F and is widely used in clinical practice to treat inflammatory diseases (including inflammatory bowel disease). However, due to its severe toxicity, TG is restricted to the treatment of many diseases. Therefore, it is necessary to study a new method to obtain the attenuated and synergistic extracts from TG. Tripterygium glycosides-n2 (TG-n2) was obtained from TG by a new preparation method. In this study, we aimed to investigate the difference in the chemical compositions between TG and TG-n2, further explored its toxicity and therapeutic effects on DSS-induced colitis in mice. The major chemical compositions of TG and TG-n2 were analyzed by ultra-performance liquid chromatography (UPLC). Subsequently, acute toxicity test was applied to evaluate the toxicity difference between TG and TG-n2. Dextran sulfate sodium (DSS)-induced acute colitis model was used to explore the therapeutic effect of TG and TG-n2 and their potential mechanisms of action. We found that the chemical compositions of TG-n2 is different from TG. The main difference is the ratio of triptriolide (T11) / triptolide (T9). Acute toxicity test proved that TG-n2 was less toxic than TG. Base on this, further studies showed that TG-n2 has a similar therapeutic effect as compared to TG on attenuating the symptoms of colitis, such as diarrhea, bloody stools, body weight loss, colonic atrophy, histopathological changes, inhibiting cytokines secretion and reducing absolute lymph number. In addition, TG and TG-n2 can increase the apoptosis of T lymphocyte in vivo. Further investigated showed that TG and TG-n2 could increase the expressions of Bax and p62 on CD3-positive T cells. This study showed that oral administration of TG-n2 is safer than TG. Moreover, the attenuated TG-n2 has the similar therapeutic effect on treating experimental colitis in mice when compared to TG. Its mechanism may be related to activating the expression of Bax in T cells and inducing T cells autophagy to regulate the survival of T lymphocytes in colitis mice, thus reducing inflammation in colon. Copyright © 2019. Published by Elsevier GmbH.

基金：
This work was financially supported by the National Key Research and Development Program of China (No. 2018YFC1707900), the National Natural Science Foundation of China (Nos. 81202398 and 81703379), the Specific Research Project of State Administration of TCM of China (No. JDZX2015207), Guangdong Provincial Science and Technology Project (Nos., 2014A020221035, 2015A020211025, 2015B020211013, and 2017B030314166), Guangzhou Science and Technology Project (Nos. 201607010338 and 201604016065), Special Funds for Inheriting and Developing the Traditional Chinese Medicine from TCM Bureau of Guangdong Province (Nos. 20191137 and 20191142), the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine (Nos. YN2016QJ05, YN2016QJ08, and YN2015MS03), the Key Project of High-level University Construction of Guangzhou University of Chinese Medicine (Nos. A1-AFD018181Z3961; A1-AFD018171Z11097, and A1-AFD018181A34).

基金编号： No. 2018YFC1707900

语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 1 区 全科医学与补充医学 2 区 药物化学 2 区 药学 2 区 植物科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 药物化学 1 区 全科医学与补充医学 1 区 药学 1 区 植物科学
JCR分区：
出版当年[2017]版：
Q1 PLANT SCIENCES Q1 PHARMACOLOGY & PHARMACY Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
最新[2023]版：
Q1 CHEMISTRY, MEDICINAL Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 PHARMACOLOGY & PHARMACY Q1 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China
共同第一作者：
通讯作者：
通讯机构： [1]The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China [3]Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, PR China [4]Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China
推荐引用方式(GB/T 7714)：
Yang Y Q,Wu Y F,Xu F F,et al.Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modulating immune homeostasis in mice.[J].PHYTOMEDICINE.2019,58:doi:10.1016/j.phymed.2019.152855.
APA：
Yang Y Q,Wu Y F,Xu F F,Deng J B,Wu L L...&Liu B.(2019).Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modulating immune homeostasis in mice..PHYTOMEDICINE,58,
MLA：
Yang Y Q,et al."Tripterygium glycoside fraction n2: Alleviation of DSS-induced colitis by modulating immune homeostasis in mice.".PHYTOMEDICINE 58.(2019)

相关文献

[1]The Effectiveness and Safety of Tripterygium wilfordii Hook. F Extracts in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis [2]Efficacy and Safety of Tripterygium Wilfordii Hook F on Psoriasis Vulgaris: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [3]Triptolide: Medicinal chemistry, chemical biology and clinical progress [4]Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology [5]Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer [6]Triptolide: Medicinal chemistry, chemical biology and clinical progress [7]Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology [8]Ginsenoside Rc attenuates DSS-induced ulcerative colitis, intestinal inflammatory, and barrier function by activating the farnesoid X receptor [9]ANALYSIS OF COAGULATION FUNCTION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE [10]Caveolin-1 protects against DSS-induced colitis through inhibiting intestinal nitrosative stress and mucosal barrier damage in mice.

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号