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LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Hua Rui-Xi[1,2] * ; Zhuo Zhenjian[3] * ; Zhu Jinhong[4] ; Zhang Shao-Dan[1] ; Xue Wen-Qiong[1] ; Li Xi-Zhao[1] ; He Jing[1,5,*1] ; Jia Wei-Hua[1,*1] ;
机构： [1]Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China [2]Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China [3]School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China [4]Department of Clinical Laboratory, Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China [5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
出处：
DOI： 10.1016/j.gene.2019.04.072
ISSN：

关键词： LIG3 Polymorphism Gastric cancer Case-control Susceptibility

摘要：
DNA ligase III (LIG3) has been implicated in the etiology of cancer. However, few studies have accessed the association of LIG3 single nucleotide polymorphisms (SNPs) with gastric cancer risk, especially in Chinese population. The current study was undertaken to investigate contribution of LIG3 gene polymorphisms to gastric cancer risk. We first applied TaqMan assay to genotype three LIG3 gene SNPs (rs1052536 C > T, rs3744356 C > T, rs4796030 A > C) in 1142 patients with gastric cancer and 1173 healthy controls. And then, we adopted unconditional multivariate logistic regression analysis to estimate the association between LIG3 SNP genotypes and gastric cancer risk. In all, no positive association was found between the three LIG3 SNPs and gastric cancer risk in single locus analysis or combined risk genotypes analysis. However, compared with participants with rs4796030 AA genotype, participants with the AC/CC had a decreased risk of developing tumors from cardia at an adjusted OR of 0.68 (95% CI = 0.48-0.96, P = 0.026). In addition, we found that participants harboring 2-3 risk genotypes were at a significantly increased risk of developing tumor from cardia (adjusted OR = 1.63, 95% CI = 1.16-2.28, P = 0.005). These results suggest that genetic variations in LIG3 gene may play a weak role in modifying the risk of gastric cancer. Future functional studies should be performed to elucidate the biological role of LIG3 polymorphisms in gastric cancer carcinogenesis. Copyright © 2019 Elsevier B.V. All rights reserved.

基金：
Natural Science Foundation of Guangdong Province (No. 2015A030310324) and National Natural Science Foundation of China (No. 81502046).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 生物
小类 | 4 区 遗传学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学
JCR分区：
出版当年[2017]版：
Q3 GENETICS & HEREDITY
最新[2023]版：
Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China [2]Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China [5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China [*1]Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, Guangdong, China.
推荐引用方式(GB/T 7714)：
Hua Rui-Xi,Zhuo Zhenjian,Zhu Jinhong,et al.LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population.[J].GENE.2019,705:90-94.doi:10.1016/j.gene.2019.04.072.
APA：
Hua Rui-Xi,Zhuo Zhenjian,Zhu Jinhong,Zhang Shao-Dan,Xue Wen-Qiong...&Jia Wei-Hua.(2019).LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population..GENE,705,
MLA：
Hua Rui-Xi,et al."LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population.".GENE 705.(2019):90-94

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