机构：[1]Department of Ophthalmology, Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA[3]MS Center of Excellence, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA[4]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China
Purpose: The goal of this work was to determine whether the retinal tissue perfusion (RTP) is impaired in patients with multiple sclerosis (MS). Methods: Seventy-four patients [66 relapsing-remitting MS (RRMS) and 8 clinically isolated syndrome (CIS)] and 74 age- and gender-matched healthy controls were recruited. RTP was calculated as the retinal blood flow (measured using retinal function imager) supplying the macular area divided by the corresponding tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer, as measured by ultrahigh-resolution optical coherence tomography. Results: The RTP in the MS group was 2.37 ± 0.59 nl/s/mm3 (mean ± standard deviation), which was significantly lower than the control group (4.06 ± 0.89 nl/s/mm3, P < .001), reflecting a decrease of 42%. The blood flow volume was 2.50 ± 0.50 nl/s in MS, which was 45% lower than in the control group (4.56 ± 0.91 nl/s, P < .001). In addition, the tissue volume of the inner retina was significantly lower than in the control group (P < .05). The RTP in patients with MS was significantly correlated with the retinal blood flow volume (r = 0.84, P < .001) and retinal tissue volume (r = -0.56, P < .001). However, the retinal blood flow in patients with MS was not related to the tissue volume (r = -0.06, P = .59). Conclusions: Impaired retinal tissue perfusion occurred in patients with MS, which could be developed as a possible biomarker in monitoring disease progression in MS.
基金：
National Multiple Sclerosis Society
(RG-1506-04890), an NIH Center Grant P30 EY014801, and a grant from
Research to Prevent Blindness (RPB).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|3 区眼科学
最新[2025]版：
大类|4 区医学
小类|4 区眼科学
第一作者：
第一作者机构：[1]Department of Ophthalmology, Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
共同第一作者：
通讯作者：
通讯机构：[2]Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA[3]MS Center of Excellence, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA[*1]Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, McKnight Building Room 202A, Miami, FL 33136, USA
推荐引用方式(GB/T 7714)：
Liu Yi,Delgado Silvia,Jiang Hong,et al.Retinal Tissue Perfusion in Patients with Multiple Sclerosis.[J].Current eye research.2019,44(10):1091-1097.doi:10.1080/02713683.2019.1612444.
APA：
Liu Yi,Delgado Silvia,Jiang Hong,Lin Ying,Hernandez Jeffrey...&Wang Jianhua.(2019).Retinal Tissue Perfusion in Patients with Multiple Sclerosis..Current eye research,44,(10)
MLA：
Liu Yi,et al."Retinal Tissue Perfusion in Patients with Multiple Sclerosis.".Current eye research 44..10(2019):1091-1097
