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Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK).

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收录情况： ◇ SCIE

作者：
Ning Jie[1,2] * ; Zhao Chengjiang[2] ; Chen Jian-Xiong[4] ; Liao Duan-Fang[1,3] ;
机构： [1]Division of Stem Cell Regulation and Application, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha,Hunan, 410208, China [2]Department of Endocrinology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua Central Hospital, Shenzhen,Guangdong, 518110, China [3]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan,410208, China [4]Department of Pharmacology and Toxicology, University of Mississippi Medical Center, School of Medicine, Jackson, MS, 39216, USA
出处：
DOI： 10.1016/j.bbrc.2019.04.073
ISSN：

关键词： Oleate acid Autophagy p38 ATF-2 Ulk1

摘要：
Hepatic autophagy plays an important role in lipid metabolism, especially in nonalcoholic fatty liver disease. The relationship between Oleate acid and autophagy is not yet clear. In this work, using mouse epithelial cell hepa1c1c7, we investigated the role of Oleate acid on autophagy and explored its potential mechanisms. The exposure of hepatic cells to Oleate acid resulted in a significant reduction of LC3 accumulation together with enhancement of p62 protein expression and the mRNA levels of ATG7 and BECN1 were reduced as well. Mechanistically, the inhibitory effects of Oleate acid on rapamycin-induced autophagy were completely blocked by treatment with dominant negative p38α and p38 inhibitor SB203580. Furthermore, ATF-2, downstream of p38, was activated by Oleate treatment. Oleate treatment also inhibited the ULK1 promoter and decreased the ULK1 mRNA level. Our data therefore suggest that Oleate activated the ATF-2 via p38 kinase which inhibited the ULK1 via binding to ULK1 promoter, and eventually the rapamycin-induced autophagy was suppressed. Copyright © 2019 Elsevier Inc. All rights reserved.

基金：
This work was supported by grants from the National Natural Sciences Foundation of China (No. 81670268, 31371161 to Liao DF), Key Laboratory Funding from Longhua District, Shenzhen (20150827A0410012), Shenzhen Foundation of Science and Technology (JCYJ20160428141615317), The Fund of Natural Science Foundation of Guangdong Province (2016A030313026), and The fund of China Hunan Provincial Science & Technology Department (2014FJ6025).
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外文
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中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 生物
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
JCR分区：
出版当年[2017]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Division of Stem Cell Regulation and Application, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha,Hunan, 410208, China [2]Department of Endocrinology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua Central Hospital, Shenzhen,Guangdong, 518110, China
通讯作者：
通讯机构： [1]Division of Stem Cell Regulation and Application, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha,Hunan, 410208, China [3]Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan,410208, China [*1]School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China.
推荐引用方式(GB/T 7714)：
Ning Jie,Zhao Chengjiang,Chen Jian-Xiong,et al.Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK).[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2019,514(1):92-97.doi:10.1016/j.bbrc.2019.04.073.
APA：
Ning Jie,Zhao Chengjiang,Chen Jian-Xiong&Liao Duan-Fang.(2019).Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK)..BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,514,(1)
MLA：
Ning Jie,et al."Oleate inhibits hepatic autophagy through p38 mitogen-activated protein kinase (MAPK).".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 514..1(2019):92-97

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