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Phenylpropanoid glycosides from the fruit of Lycium barbarum L. and their bioactivity.

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机构： [1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China [2]Clinical Medicine Research Institute, The First Affiliated Hospital of Jinan University, Guangzhou 510632, People's Republic of China [3]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, People's Republic of China [4]Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China [5]Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University, Guangzhou, 510632, People's Republic of China

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关键词： Lycium barbarum L (Solanaceae) Goji Wolfberry Phenylpropanoid glycosides Antioxidant activity Hypoglycemic activity

摘要：

Fifteen phenylpropanoid glycosides, including six undescribed compounds were isolated from the fruit of Lycium barbarum L. (Solanaceae) (goji or wolfberry). Their structures were identified by detailed spectroscopic analyses. Seven known compounds were firstly isolated from the genus Lycium, in which the 1D and 2D NMR data of one compound were reported for the first time. Notably, two undescribed compounds were a pair of rare tautomeric glycoside anomers characterized by the presence of free anomeric hydroxy. Antioxidant and hypoglycemic activities of all these compounds were assessed using DPPH radical scavenging, oxygen radical absorbance capacity (ORAC), and α-glucosidase inhibitory assays, respectively. These compounds showed different levels of oxygen radical absorbance capacity, and some isolates exhibited potent antioxidant activity with greater ORAC values than the positive control (EGCG). Copyright © 2019 Elsevier Ltd. All rights reserved.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 2 区植物科学 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生化与分子生物学 2 区植物科学

第一作者：

第一作者机构： [1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China

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通讯机构： [1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China [3]Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, People's Republic of China [*1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China

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