机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou,510515, Guangdong, China,[2]Pharmacy Intravenous Admixture Services, Taian City Central Hospital, Taian, 271000, Shandong, China,[3]Department of Cardiology, Taian City Central Hospital, Taian, 271000, Shandong, China,[4]Department of Central Laboratory, Taian City Central Hospital, Taian, 271000, Shandong, China
Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus, for which no effective treatment currently exists. We tested the hypothesis that Qi-dan-di-huang (QDDH) might have therapuetic effects in an experimental rat model of DN. The levels of I kappa KinaseAlpha and Beta, p-p65, p-IκB alpha, TGF-β1 and Alpha-SMA were significantly increased in kidneys in DN. QDDH decoction only partially reversed the increased Ikappa KinaseAlpha/Beta, p-p65, p-IKappaB alpha, TGF-Beta1 and alpha-SMA in the kidneys in DN. However, treatment of diabetic rats with QDDH decoction significantly inhibited the production and release of inflammatory cytokines IL-6, IL-1 beta and TNF-alpha into the serum. QDDH decoction also significantly improved the physiologic and biochemical indicators of DN, reduced glycogen and protein deposition in DN and prevented renal fibrosis. Together, the data show that QDDH decoction exerts a protective effect on kidneys in diabetic rats and reverses the inflammatory milieu of the serum in DN.
基金：
This work was supported by
funding from the National Natural Science Foundation
of China (NSFC81573812 and NSFC81673840).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
无
最新[2025]版：
大类|4 区生物学
小类|4 区生化与分子生物学4 区细胞生物学
第一作者：
第一作者机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou,510515, Guangdong, China,[2]Pharmacy Intravenous Admixture Services, Taian City Central Hospital, Taian, 271000, Shandong, China,
通讯作者：
通讯机构：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou,510515, Guangdong, China,[*1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China
推荐引用方式(GB/T 7714)：
Fei Ma,Lingxing Li,Qian Wang,et al.Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway.[J].Frontiers in bioscience (Landmark edition).2019,24:1477-1486.
APA：
Fei Ma,Lingxing Li,Qian Wang,Zujiang Chen,Yanting You...&Ren Luo.(2019).Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway..Frontiers in bioscience (Landmark edition),24,
MLA：
Fei Ma,et al."Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway.".Frontiers in bioscience (Landmark edition) 24.(2019):1477-1486
