机构：[1]College of Pharmacy, Jinan University, Guangzhou 510632, PR China[2]Guangzhou Hospital of Integrated Traditional Chinese & Western Medicine, Guangzhou 510800, PR China[3]Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCM, Zhongshan, Guangdong 528400, PR China深圳市中医院深圳医学信息中心[4]College of Life Sciences, Liaoning University, Shenyang 110036, PR China[5]Cancer Research Institute of Jinan University, Guangzhou 510632, PR China
Breast cancer is the most common female cancer worldwide and represents 12% of all cancer cases. Improvements in survival rates are largely attributed to improved screening and diagnosis. Conventional chemotherapy remains an important treatment option but it is beset with poor cell selectivity, serious side effects and resistance. Nanoparticle drug delivery systems bring promising opportunities to breast cancer treatment. They may improve chemotherapy by targeting drugs to tumors, generating high drug concentrations at tumors providing slow release of the drug, increased drug stability and concomitant reductions in side effects. The nanotechnology-based drug delivery approaches and the current research and application status of nano-targeted agents for breast cancer are discussed in this review to provide a basis for further study on targeted drug delivery systems.
基金：
This review was financially supported by the National Natural Science Foundation of China (81173215, 81273707); the Natural
Science Foundation of Guangdong (2016A030311037); the Science and Technology Program of Guangzhou (2014J4500005,
201704030141); the Science Program of the Department of Education of Guangdong (2015KGJHZ012); the Science and Technology
Program of Guangdong (2015A050502027); and the Special Project of International Scientific and Technological Cooperation
in Guangzhou Development District (2017GH16).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区医学
小类|2 区生物工程与应用微生物3 区纳米科技
最新[2025]版：
大类|4 区医学
小类|3 区生物工程与应用微生物4 区纳米科技
第一作者：
第一作者机构：[1]College of Pharmacy, Jinan University, Guangzhou 510632, PR China
共同第一作者：
通讯作者：
通讯机构：[1]College of Pharmacy, Jinan University, Guangzhou 510632, PR China[5]Cancer Research Institute of Jinan University, Guangzhou 510632, PR China
推荐引用方式(GB/T 7714)：
Manling Du,Yong Ouyang,Fansu Meng,et al.Nanotargeted agents: an emerging therapeutic strategy for breast cancer.[J].Nanomedicine (London, England).2019,14(13):1771-1786.doi:10.2217/nnm-2018-0481.
APA：
Manling Du,Yong Ouyang,Fansu Meng,Qianqian Ma,Hui Liu...&Yu Cai.(2019).Nanotargeted agents: an emerging therapeutic strategy for breast cancer..Nanomedicine (London, England),14,(13)
MLA：
Manling Du,et al."Nanotargeted agents: an emerging therapeutic strategy for breast cancer.".Nanomedicine (London, England) 14..13(2019):1771-1786
