机构:[1]Hainan General Hospital, Haikou, China,[2]Jiaozuo Second People’s Hospital, Jiaozuo, China[3]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou, China
Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely adverse effects. Recently, certain natural products have been reported to overcome MDR, including flavonoids which are abundant in plants, foods, and herbs. The structure of flavonoids can be abbreviated as C6-C3-C6 (C for carbon), and further categorized into flavonoids, iso-flavonoids and neo-flavonoids, according to their structural backbones. Flavonoids possess multiple bioactivities, and a growing body of research has indicated that both flavonoids and iso-flavonoids can either kill or re-sensitize conventional chemotherapeutics to resistant cancer cells. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to MDR.
基金:
This research was funded by the Hainan Provincial Natural
Science Foundation of China (Grant number: 817307).
语种:
外文
PubmedID:
中科院(CAS)分区:
出版当年[2018]版:
大类|2 区医学
小类|3 区肿瘤学
最新[2025]版:
大类|3 区医学
小类|4 区肿瘤学
第一作者:
第一作者机构:[1]Hainan General Hospital, Haikou, China,
通讯作者:
推荐引用方式(GB/T 7714):
Qingmei Ye,Kai Liu,Qun Shen,et al.Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids.[J].Frontiers in oncology.2019,9:487.doi:10.3389/fonc.2019.00487.
APA:
Qingmei Ye,Kai Liu,Qun Shen,Qingyue Li,Jinghui Hao...&Ren-Wang Jiang.(2019).Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids..Frontiers in oncology,9,
MLA:
Qingmei Ye,et al."Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids.".Frontiers in oncology 9.(2019):487