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Global cytokine/chemokine profile identifies potential progression prediction indicators in hand-foot-and-mouth disease patients with Enterovirus A71 infections.

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机构: [1]Major Infectious Disease Control Key Laboratory, The Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China [2]Department of Biomedical Science, The City University of Hong Kong, China [3]The Zhenzhou Hospital of Traditional Chinese Medicine, Zhenzhou, Henan Province, China [4]The Cancer Institute, Zhongshan People’s Hospital, Zhongshan, Guangdong Province, China [5]Division of Biostatistics, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region [6]The CUHK Shenzhen Research Institute, Shenzhen, China [7]The CityU Shenzhen Research Institute, Shenzhen, Guangdong Province, China
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关键词: EV-A71 Hand-foot-and-mouth disease Cytokine/chemokine array Indicator Inflammation profile

摘要:
New clinical indicators are urgently needed for predicting the progression and complications of hand-foot-and-mouth disease (HFMD) caused by EV-A71 infections. Serum specimens from 132 EV-A71 HFMD patients and 73 health children were collected during 2012-2014 in Shenzhen, China. The specific cytokines/chemokines were detected with a 274-human cytokine antibody array, followed by a 38-inflammation cytokine array, and further validated by ELISA. Cytokines varied in different severity of EV-A71 HFMD patients. The ROC curve analysis revealed 5 serum cytokines with high sensitivity and specificity in predicting the disease progression. Eotaxin, IL-8 and IP-10 have showed high AUC values (0.90-0.95) for discrimination between the health controls and the patient group. The three cytokines showed high sensitivity (80-91%) and specificity (88-95%). MMP-8 had a high sensitivity and specificity to predict mild HFMD (100%, 100%). IL-1b and leptin discriminated the severe/critical group from the mild group (79% and 69% in sensitivity, 73% and 63% in specificity). Eotaxin, IP-10 and IL-8 could be potential indicators for predicting HFMD progression with EV-A71 infection. MMP-8 is a specific indicator for mild infection, while IL-1b and leptin display potential for predicting the severity and criticality. Copyright © 2019 Elsevier Ltd. All rights reserved.

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 免疫学 4 区 细胞生物学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 生化与分子生物学 3 区 细胞生物学 3 区 免疫学
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第一作者机构: [1]Major Infectious Disease Control Key Laboratory, The Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China
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通讯机构: [2]Department of Biomedical Science, The City University of Hong Kong, China [7]The CityU Shenzhen Research Institute, Shenzhen, Guangdong Province, China [*1]The City University of Hong Kong, Hong Kong Special Administrative Region
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