机构：[1]Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang 524023, China[2]Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of MedicalMolecular Diagnostics, Guangdong Medical University, Dongguan 523808, China[3]Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China[4]Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.5Department of Blood Internal Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China[6]Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642,China[7]School of Chinese Medicine, The University of Hongkong, Pokfulam, Hongkong[8]Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China
Yunnan Baiyao (YB) as a kind of famous Chinese herbal medicine, possessed hemostatic, invigorating the circulation of blood, and anti-inflammatory effects. Identifying strategies to protect patients at risk for hospital-acquired pressure ulcers (HAPU) is essential. Herein, our results showed that YB treatment can effectively reduce the acne wound area and improve efficacy in a comparative study of 60 cases HAPU patients with S. aureus positive of acne wound pathogens. Furthermore, YB inhibited HIa expression and suppressed accessory gene regulator (agr) system controlled by regulatory RNA II and RNA III molecule using pALC1740, pALC1742 and pALC1743 S. aureus strain linked to gfpuvr reporter gene. Moreover, YB downregulated cao mRNA expression and inhibited coagulase activity by RT-PCR, slide and tube coagulase test. Additionally, YB downregulated seb, sec, sed, and tsst-1 mRNA expression to suppress enterotoxin and tsst-1 secretion and adhesion function related genes sarA, icaA, and cidA mRNA expression. Taken together, the data suggest that YB may reduce HAPU via suppressing virulence gene expression and biofilm formation of S. aureus.
基金：
Traditional Chinese
Medicine Bureau of Guangdong Province (20151261),
Natural Science Foundation of Guangdong
(2016A030313151, 2016A030313674, 2015A030310046),Science and Technology Planning Project of
Guangdong Province (2017A020217002,
2016A020215224), Finance Special Project of
Zhanjiang City (2013A01007, 2015A01036), and the
General Projects of Guangdong Medical College
(M2015007).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：内科
最新[2025]版：
大类|3 区医学
小类|3 区医学：内科
第一作者：
第一作者机构：[1]Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang 524023, China[2]Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of MedicalMolecular Diagnostics, Guangdong Medical University, Dongguan 523808, China
通讯作者：
通讯机构：[2]Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of MedicalMolecular Diagnostics, Guangdong Medical University, Dongguan 523808, China[6]Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642,China[*1]Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan 523808, China[*2]College of Marine Science, South China Agricultural University, Guangzhou 510642, China
推荐引用方式(GB/T 7714)：
Jun Liu,Mufa Cai,Huimin Yan,et al.Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus.[J].International journal of medical sciences.2019,16(8):1078-1088.doi:10.7150/ijms.33723.
APA：
Jun Liu,Mufa Cai,Huimin Yan,Jiawu Fu,Guocai Wu...&Jincheng Zeng.(2019).Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus..International journal of medical sciences,16,(8)
MLA：
Jun Liu,et al."Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus.".International journal of medical sciences 16..8(2019):1078-1088
