详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

GRP78 overexpression as an unfavorable outcome in glioma patients.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Zhongshan Chenxinghai Hospital, Guangdong Medical University, Zhongshan, China [2]Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China [3]Department of Neurosurgery, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, China

出处：

关键词： GRP78 overexpression glioma disease progression outcome

摘要：

In this study, the GRP78 expression and the correlation between GRP78 expression and clinicopathologic data in patients with glioma, including survival, were examined. The mRNA and protein levels of GRP78were respectively determined by real-time PCR and immunohistochemical analysis in 30 fresh glioma samples and 19 fresh normal brain samples as well as 156 paraffin-embedded glioma samples and 35 normal paraffin-embedded brain samples. The data showed that GRP78 mRNA is markedly upregulated compared with normal brain tissues. Consistent with this data, the GRP78 protein level was also significantly increased in glioma tissues compared with normal brain tissues. We further observed that high GRP78 protein expression was significantly associated with clinical stage (P = 0.0013) but did not correlate with age and gender. High, rather than low, GRP78 protein expression was associated with pooroverall survival rates (P = 0.001). Multivariate analysis indicated that high GRP78 protein expression was an independent prognostic indicator of patient survival (P = 0.002). Our findings demonstrate that GRP78 is overexpressed and plays a significant role in disease progression and poor outcome in patients with glioma. IJCEP Copyright © 2018.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

第一作者：

第一作者机构： [1]Zhongshan Chenxinghai Hospital, Guangdong Medical University, Zhongshan, China

通讯作者：

通讯机构： [2]Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China [*1]Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510310, Guangdong, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]PGK1 and GRP78 overexpression correlates with clinical significance and poor prognosis in Chinese endometrial cancer patients. [2]Gut microbiota composition reflects disease progression, severity and outcome, and dysfunctional immune responses in patients with hypertensive intracerebral hemorrhage [3]Overexpression of TIP30 inhibits the growth and invasion of glioma cells. [4]A multicenter 10-year oncologic outcome of ultrasound-guided percutaneous microwave ablation of clinical T1 renal cell carcinoma: will it stand the test of time? [5]肺结核患者体内结核病相关免疫细胞因子的动态变化 [6]GRP94 overexpression as an indicator of unfavorable outcomes in breast cancer patients. [7]Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis. [8]Textbook Outcome as a Composite Outcome Measure in Laparoscopic Pancreaticoduodenectomy [9]Performance of Passive Muscle Stiffness in Diagnosis and Assessment of Disease Progression in Duchenne Muscular Dystrophy. [10]Renal primary cilia lengthen in the progression of diabetic kidney disease