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Low MYH9 expression predicts a good prognosis for hepatocellular carcinoma.

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机构： [1]Integrated Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [2]Cancer Center, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China [3]Department of Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China [4]Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, China

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关键词： MYH9 hepatocellular carcinoma prognosis bioinformatics analysis immunohistochemistry

摘要：

Hepatocellular carcinoma (HCC) is currently one of the most common causes of cancer-related death and one of the most commonly diagnosed cancers. MYH9 is thought to play a critical role in cancer progression. However, the expression and prognostic value of MYH9 in HCC are still unknown. In this study, the expression and biological significance of MYH9 were evaluated in HCC, at mRNA and protein levels. We showed that both mRNA and protein levels of MYH9 were significantly upregulated in HCC relative to the levels in adjacent non-tumor tissues based on the TCGA database and immunohistochemical analysis, respectively (P < 0.001). Additionally, we found that high MYH9 protein levels correlated with poor patient prognosis (median survival 19 months versus 49 months) (Log-Rank, P = 0.0292). Meanwhile, our data suggested that MYH9 expression is an independent prognostic factor for HCC after surgical resection (HR = 0.675, 95% CI 0.452-1.008, P = 0.054) and can potentially serve as a biomarker for the clinical diagnosis and prognosis of HCC. IJCEP Copyright © 2018.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

第一作者：

第一作者机构： [1]Integrated Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [2]Cancer Center, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China

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通讯作者：

通讯机构： [1]Integrated Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China [2]Cancer Center, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China [*1]Cancer Center, Traditional Chinese Medicine-Integrated Hospital of Southern Medical University, Courtyard No. 13, Shiliugang Road, Haizhu District, Guangzhou, Guangdong, People’s Republic of China

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