机构：[1]Department of Pathology, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China[2]School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China[3]Clinical Laboratory, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China[4]Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China[5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
Neuroblastoma is a lethal tumor of the sympathetic nervous system. 8-Hydroxydeoxyguanine (8-OH-dG) formation is a common seen type of oxidative DNA damage, which could be repaired by human oxoguanine glycosylase 1 (hOGG1). To explore the contributing role of hOGG1 gene single nucleotide polymorphisms (SNPs) in neuroblastoma risk, we performed a case-control study by genotyping three SNPs (rs1052133 G>C, rs159153 T>C, rs293795 A>G) in hOGG1 gene. A total of 512 neuroblastoma cases and 1076 cancer-free controls were enrolled from three medical centers in China. The hOGG1 gene polymorphisms were determined using TaqMan real-time PCR. The results showed that only the rs1052133 G>C polymorphism was associated with neuroblastoma risk [GC vs. GG: adjusted odds ratio (OR)=0.64, 95% confidence interval (CI)=0.51-0.81, P=0.0002; dominant model: adjusted OR=0.71, 95% CI=0.57-0.88, P=0.002]. Moreover, subjects carrying 1, 2, or 1-3 protective genotypes have less opportunity to develop neuroblastoma, in comparison to those without protective genotypes. Stratified analysis revealed that rs1052133 GC/CC carriers were less likely to develop neuroblastoma in subgroups of age >18 months, males, tumor that develops from retroperitoneal, mediastinum and clinical stage I+II+4s. Our results indicate that hOGG1 rs1052133 G>C polymorphism is associated with decreased risk of neuroblastoma. However, the exact biological mechanism awaits further research.
基金：
the Pearl
River S&T Nova Program of Guangzhou (No:
201710010086), and the State Clinical Key Specialty
Construction Project (Pediatric Surgery) 2013 (No:
GJLCZD1301).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Pathology, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China[*1]Department of Pathology, Anhui Provincial Children's Hospital, 39 East Wangjiang Road, Hefei 230051, Anhui, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pathology, Anhui Provincial Children's Hospital, Hefei 230051, Anhui, China[5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China[*1]Department of Pathology, Anhui Provincial Children's Hospital, 39 East Wangjiang Road, Hefei 230051, Anhui, China[*2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, China
推荐引用方式(GB/T 7714)：
Wang Yi-Zhen,Zhuo Zhen-Jian,Fang Yuan,et al.Functional Polymorphisms in hOGG1 Gene and Neuroblastoma Risk in Chinese Children.[J].Journal of Cancer.2018,9(23):4521-4526.doi:10.7150/jca.27983.
APA：
Wang Yi-Zhen,Zhuo Zhen-Jian,Fang Yuan,Li Lin,Zhang Jiao...&Wu Xue-Mei.(2018).Functional Polymorphisms in hOGG1 Gene and Neuroblastoma Risk in Chinese Children..Journal of Cancer,9,(23)
MLA：
Wang Yi-Zhen,et al."Functional Polymorphisms in hOGG1 Gene and Neuroblastoma Risk in Chinese Children.".Journal of Cancer 9..23(2018):4521-4526
