机构：[1]Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,[2]Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University,中山大学附属第一医院[3]Department of Traditional Chinese Medicine Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangdong,[4]Department of Laboratory Medicine and Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Heilongjiang,[5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, People’s Republic of China
Previous studies have reported that XPC gene polymorphisms may modify the individual susceptibility to gastric cancer. In this case-control study with a total of 1,142 cases and 1,173 controls, four potentially functional polymorphisms were genotyped in the XPC gene (rs2228001 A>C, rs2228000 C>T, rs2607775 C>G, and rs1870134 G>C) by Taqman assays and their associations were analyzed with the risk of gastric cancer in a Southern Chinese population. No significant association between any of XPC polymorphisms and gastric cancer risk was detected except for a borderline association with the rs2228000 CT/TT genotype (crude odds ratio =0.86, 95% confidence interval =0.73-1.02, P=0.088) when compared to the rs2228000 CC genotype. Further stratified analysis revealed that the protective effect of rs2228000 CT/TT on the risk of gastric cancer was only significant among subjects older than 58 years. In summary, results indicated that genetic variations in XPC gene may play a weak effect on gastric cancer susceptibility in Southern Chinese population, which warrants further confirmation in larger prospective studies with different ethnic populations.
基金：
This study was supported by grants from the National Natural Science Foundation of China (Grant No 81502046), Special Financial Grant from the China Postdoctoral Science Foundation (Grant No 2014T70836), the Natural Science Foundation of Guangdong Province (Grant No 2015A030310324), and the National Science Fund for Distinguished Young Scholars (Grant No 81325018).
第一作者机构：[1]Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,[2]Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,[5]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, People’s Republic of China[*1]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, People’s Republic of China[*2]Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, Guangdong, People’s Republic of China
推荐引用方式(GB/T 7714)：
Rui-Xi Hua,Zhen-Jian Zhuo,Guo-Ping Shen,et al.Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population.[J].ONCOTARGETS AND THERAPY.2016,9:5513-5519.doi:10.2147/OTT.S113055.
APA：
Rui-Xi Hua,Zhen-Jian Zhuo,Guo-Ping Shen,Jinhong Zhu,Shao-Dan Zhang...&Wei-Hua Jia.(2016).Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population..ONCOTARGETS AND THERAPY,9,
MLA：
Rui-Xi Hua,et al."Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population.".ONCOTARGETS AND THERAPY 9.(2016):5513-5519
