详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

The emerging role of NPNT in tissue injury repair and bone homeostasis.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]The National Key Discipline and the Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China [2]Department of Orthopedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China [3]School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA, Australia

出处：

DOI：

ISSN：

关键词： angiogenesis EGF-like kidney development nephronectin osteoblast

摘要：

Nephronectin (NPNT), a highly conserved extracellular matrix protein, plays an important role in regulating cell adhesion, differentiation, spreading, and survival. NPNT protein belongs to the epidermal growth factor (EGF)-like superfamily and exhibits several common structural determinants; including EGF-like repeat domains, MAM domain (Meprin, A5 Protein, and Receptor Protein-Tyrosine Phosphatase µ), RGD motif (Arg-Gly-Asp) and a coiled-coil domain. It regulates integrins-mediated signaling pathways via the interaction of its RGD motif with integrin α8β1. Recent studies revealed that NPNT is involved in kidney development, renal injury repair, atrioventricular canal differentiation, pulmonary function, and muscle cell niche maintenance. Moreover, NPNT regulates osteoblast differentiation and mineralization, as well as osteogenic angiogenesis. Altered expression of NPNT has been linked with the progression of certain types of cancers, such as spontaneous breast tumor metastasis and malignant melanoma. Interestingly, NPNT gene expression can be regulated by a range of external factors such as tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), oncostatin M (OSM), bone morphogenic protein 2 (BMP2), Wnt3a, Vitamin D3 , and microRNA-378 (miR378). Further understanding the cellular and molecular mechanisms by which NPNT regulates tissue homeostasis in an organ-specific manner is critical in exploring NPNT as a therapeutic target for tissue regeneration and tissue engineering. © 2017 Wiley Periodicals, Inc.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2017]版：

大类 | 2 区生物

小类 | 2 区生理学 3 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区细胞生物学 3 区生理学

第一作者：

第一作者机构： [1]The National Key Discipline and the Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China [2]Department of Orthopedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China [3]School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA, Australia

通讯作者：

通讯机构： [1]The National Key Discipline and the Orthopedic Laboratory, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, P. R. China [3]School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, WA, Australia [*1]School of Pathology and Laboratory Medicine, The University of Western Australia, QEII Medical Centre, 1st Floor M Block, Perth, WA, 6009, Australia.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis. [2]Lysophosphatidic acid enhanced the osteogenic and angiogenic capability of osteoblasts via LPA1/3 receptor. [3]A chronic kidney disease patient awareness questionnaire: Development and validation [4]Primary cilium in kidney development, function and disease [5]Development and validation of a nomogram model for medication non-adherence in patients with chronic kidney disease [6]miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature [7]成骨细胞分化、骨形成与修复中转录因子Osx和Satb2的调控作用 [8]淫羊藿苷通过提高自噬促进成骨细胞分化防治骨质疏松 [9]METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis [10]Regulation of bone formation by baicalein via the mTORC1 pathway.