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Phenylisotertronic acids from the TCM endophytic fungus Phyllosticta sp.

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机构: [1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China [2]State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China [3]Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510632, China
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关键词: Phenylisotertronic acids Isotertronic acids Phyllosticta sp Acorus tatarinowii TCM endophytic fungus

摘要:
Four new phenylisotertronic acids (1a/1b, 2a, and 3a) were isolated from a TCM endophytic fungal strain Phyllosticta sp. J13-2-12Y obtained from the leaves of Acorus tatarinowii, along with two known ones (2b and 3b). Compounds 1-3 all existed as mixtures of enantiomers, and their corresponding optically pure enantiomers were successfully isolated by chiral HPLC. The structures of isolated compounds were determined by comprehensive spectroscopic analyses and X-ray diffraction. Their absolute configurations were determined by ECD experiments and quantum chemical calculations. In addition, the antimicrobial activities and the cytotoxicities of these three pairs of optically pure enantiomers (1a/1b, 2a/2b, and 3a/3b) had been evaluated. Copyright © 2017 Elsevier B.V. All rights reserved.

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出版当年[2017]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
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第一作者机构: [1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
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通讯机构: [1]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China [2]State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China [*2]Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
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