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Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus.

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机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China [b]Henan University of Chinese Medicine, Zhengzhou 450008, People's Republic of China [c]Department of Pharmaceutical Preparation, Affiliated Chinese Medicine Hospital of the Southwest Medical University, Luzhou 646000, People's Republic of China [d]Southwest Medical University, Luzhou 646000, People's Republic of China [e]Yunnan University of Traditional Chinese Medicine, Kunming 650500, People's Republic of China [f]Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China

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关键词： Clerodendranthus spicatus Diterpenoids Alkaloid Cytotoxic activities Renal fibrosis

摘要：

Three new diterpenoids, spicatusenes A-C (1-3), and eleven known ones (4-14) were isolated from the aerial parts of Clerodendranthus spicatus. Their structures were identified by spectroscopic methods. The cytotoxic activities of all the compounds against human cancer cells (HL-60, SMMC-7721, A-549, MCF-7, and SW-480) were examined and found that compounds 2, 3, 6, 8, 10, and 13 were active against one or more cancer cell lines. Besides, the renoprotective effects of all the isolates in TGF-β1-induced rat kidney fibroblasts revealed that compounds 3-7, 9, 13, and 14 were beneficial for renal fibrosis. Finally, a plausible biosynthetic pathway for 1 via a Hantzsch-type reaction was proposed. Copyright © 2018. Published by Elsevier B.V.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

第一作者：

第一作者机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China [c]Department of Pharmaceutical Preparation, Affiliated Chinese Medicine Hospital of the Southwest Medical University, Luzhou 646000, People's Republic of China

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通讯作者：

通讯机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China [b]Henan University of Chinese Medicine, Zhengzhou 450008, People's Republic of China [c]Department of Pharmaceutical Preparation, Affiliated Chinese Medicine Hospital of the Southwest Medical University, Luzhou 646000, People's Republic of China [d]Southwest Medical University, Luzhou 646000, People's Republic of China [f]Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, People's Republic of China [*1]Department of Pharmaceutical Preparation, Affiliated Chinese Medicine Hospital of the Southwest Medical University, Luzhou 646000, People's Republic of China [*2]Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei Road 132, 650204 Kunming, People's Republic of China.

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