机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China[2]Immunity and Biochemical Research Lab, Zhejiang Academy of Medical Sciences, Hangzhou, China[3]Guangdong Institute of Microbiology, Guangzhou, China[4]Institute of Marine Medicine Research, Guangdong Medical University, Zhanjiang, China[5]Forensic Identification Institute, Guangdong Women and Children Hospital, Guangzhou, China[6]The Affiliated Hospital Cancer Center, Guangdong Medical University, Zhanjiang, China[7]Department of Blood Transfusion, Peking University Shenzhen Hospital, Shenzhen, China北京大学深圳医院深圳市康宁医院深圳医学信息中心[8]School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China[9]Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China[10]Cancer Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA[11]Institute of Bioinformatics, University of Georgia, Athens, GA, USA[12]Key Laboratory of Orthopaedics and Traumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
Previous studies showed that the low expressions of chromodomain-helicase-DNA-binding protein 5 (CHD5) were intensively associated with deteriorative biologic and clinical characteristics as well as outcomes in many tumors. The aim of this study is to determine whether CHD5 single nucleotide polymorphisms (SNPs) contribute to the prognosis of hepatocellular carcima (HCC). The SNPs were selected according to their linkage disequilibrium (LD) in the targeted next-generation sequencing (NGS) and then genotyped with TaqMan probers. We revealed a rare haplotype AG in CHD5 (SNPs: rs12564469-rs9434711) was markedly associated with HCC prognosis. The univariate and multivariate regression analyses revealed the patients with worse overall survival time were those with tumor metastasis and haplotype AG, as well as cirrhosis, poor differentiation and IV-TNM stage. Based on the available public databases, we discovered the significant association between haplotype AG and CHD5 mRNA expressions only existed in Chinese. These data proposed that the potentially genetic haplotype might functionally contribute to HCC prognosis and CHD5 mRNA expressions.
基金：
This work was supported by National Natural Science Foundation of China (81541153); Guangdong Provincial Science and Technology Programs (2015A050502048, 2016A050503046, 2014A020212295, and 2014A020212653); Science and Technology Research Project in Dongguan City (2013508152011 and 2013508152002).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2025]版：
无
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China[10]Cancer Center, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA, USA[11]Institute of Bioinformatics, University of Georgia, Athens, GA, USA
共同第一作者：
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China[4]Institute of Marine Medicine Research, Guangdong Medical University, Zhanjiang, China
推荐引用方式(GB/T 7714)：
Xiao Zhu,Qingming Kong,Liwei Xie,et al.The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma.[J].Oncotarget.2018,9(17):13222-13230.doi:10.18632/oncotarget.23812.
APA：
Xiao Zhu,Qingming Kong,Liwei Xie,Zhihong Chen,Hongmei Li...&Hui Luo.(2018).The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma..Oncotarget,9,(17)
MLA：
Xiao Zhu,et al."The single-nucleotide polymorphisms in CHD5 affect the prognosis of patients with hepatocellular carcinoma.".Oncotarget 9..17(2018):13222-13230
