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Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice.

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资源类型：
Pubmed体系：
作者：
Xixi Cheng[a,c] * ; Huafeng Wang[b] * ; Jinlai Yang[a] * ; Yingnan Cheng[a] ; Dan Wang[a] ; Fengrui Yang[a] ; Yan Li[a] ; Dongmei Zhou[a] ; Yanxia Wang[b] ; Zhenyi Xue[a] ; Lijuan Zhang[a] ; Qi Zhang[a] ; Luhong Yang[b] ; Rongxin Zhang[a,d] ; Yurong Da[a,*1] ;
机构： [a]Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, China [b]School of Life Science, Shanxi Normal University, Linfen, China [c]Department of Clinical Laboratory, Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, China [d]Laboratory of Immunology and Inflammation, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China
出处：
DOI： 10.1016/j.biopha.2018.03.060
ISSN：

关键词： Arctigenin Immunological hepatitis Macrophage Inflammation

摘要：
As a phenylpropanoid and dibenzylbutyrolactone lignan present in medical plants, such as those used in traditional Chinese herbal medicine, including Arctium lappa (Niubang), arctigenin exhibits antimicrobial, anti-inflammatory, and anticancer activities. In this study, we investigated the protective role of arctigenin in Concanavalin A (ConA)-induced acute hepatitis in mice. Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo. The infiltration of CD4 T, NKT and macrophages into the livers was found to be reduced with arctigenin treatment. Arctigenin suppressed ConA-induced T lymphocyte proliferations that might have resulted from enhanced IL-10 production by macrophages and CD4 T cells. These results suggested that arctigenin could be a powerful drug candidate for acute hepatitis through immune suppression. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

基金：
This work was supported by the National Natural Science Foundation of China through Grants No. 81272317, 81541032, 31600730, and 81602496; and the Natural Science Foundation of Tianjin through Grant Nos. 16JCYBJC24600 and 16JCYBJC24800.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 3 区 药学 4 区 医学：研究与实验
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验 2 区 药学
第一作者：
第一作者机构： [a]Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, China [c]Department of Clinical Laboratory, Binhai New Area Hospital of Traditional Chinese Medicine, Tianjin, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin, China [*1]Department of Immunology, Key Laboratory of Immune Microenvironment and Diseases of Educational Ministry of China and Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Qi Xiang Tai Road No.22, Tianjin, 300070, China.
推荐引用方式(GB/T 7714)：
Xixi Cheng,Huafeng Wang,Jinlai Yang,et al.Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice.[J].BIOMEDICINE & PHARMACOTHERAPY.2018,102:464-471.doi:10.1016/j.biopha.2018.03.060.
APA：
Xixi Cheng,Huafeng Wang,Jinlai Yang,Yingnan Cheng,Dan Wang...&Yurong Da.(2018).Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice..BIOMEDICINE & PHARMACOTHERAPY,102,
MLA：
Xixi Cheng,et al."Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice.".BIOMEDICINE & PHARMACOTHERAPY 102.(2018):464-471

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