机构：[1]College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China [2]Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China [3]Department of Academic Registry, Beijing University of Chinese Medicine, Beijing, 100029 PR China [4]Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI 02903, USA [5]School of Basic Medicine, Gannan Medical University, Ganzhou 341000, PR China [6]Department of Pharmacology, Guangdong Medical University, Dongguan, 523808 PR China
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG. Recent research has gained positive and promising data. This review will discuss the interaction between EGCG and mitochondrion.
基金：
This study was financially supported by the National Science Foundation of China (81660371, 21767002, and 31560260), the
National Science Foundation of Jiangxi Province (20161BAB215219), Scientific Research Fund of Jiangxi Provincial Education Department
(GJJ150949). The authors have no other relevant affiliations or financial involvement with any organization or entity
with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those
disclosed
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|2 区药物化学
最新[2025]版：
大类|4 区医学
小类|4 区药物化学
第一作者：
第一作者机构：[1]College of Pharmacy, Gannan Medical University, Ganzhou, 341000 PR China [2]Industrial Comprehensive Development & Engineering Research Center for Camellia Oleifera in Gannan Medical University, Ganzhou, 341000 PR China
共同第一作者：
推荐引用方式(GB/T 7714)：
Shi Weimei,Li Linfu,Ding Yechun,et al.The critical role of epigallocatechin gallate in regulating mitochondrial metabolism.[J].Future medicinal chemistry.2018,10(7):795-809.doi:10.4155/fmc-2017-0204.
APA：
Shi Weimei,Li Linfu,Ding Yechun,Yang Kai,Chen Zhixi...&Wu Longhuo.(2018).The critical role of epigallocatechin gallate in regulating mitochondrial metabolism..Future medicinal chemistry,10,(7)
MLA：
Shi Weimei,et al."The critical role of epigallocatechin gallate in regulating mitochondrial metabolism.".Future medicinal chemistry 10..7(2018):795-809
：