机构：[1]Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan.[2]Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.[3]Department of Biological Science, Asia University, Taichung, Taiwan.[4]Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.[5]Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.[6]School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan.[7]Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.[8]Department of Biotechnology, Bharathiar University, Coimbatore, India.[9]Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.[10]Department of Clinical Laboratory, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangdong, China.[11]Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
Eriobotrya japonica (EJ) is a traditional Chinese plant with high medicinal value. EJ extracts are reported to exhibit antioxidant and anti-inflammatory biological attributes. The current study aims to evaluate the prospective efficacy of E. japonica leave extract (EJLE) against Angiotensin-II induced cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats (SHRs). For the in vitro studies, Angiotensin-II pretreated H9c2 cells were treated with EJLE and analyzed through Western blotting and rhodamine phalloidin staining for their cardio-protective attributes. In the in vivo studies, 12-week-old SHRs were randomly divided into groups: SHRs supplemented with EJLE, control SHR group supplemented with PBS; in addition, a control group of Wistar-Kyoto rats (WKY) was also employed. All rats were supplemented twice a week for 8 week time interval. Finally, echocardiography, morphological, histology, and Western blot analysis were performed to assess their role against cardiac hypertrophy. Interestingly, we could observe that supplementation of EJLE could rescue Ang-II induced cardiac hypertrophy as evident through Western blot, rhodamine phalloidin staining, and Hematoxylin-Eosin staining. Notably, morphological and echocardiography data provided further supports for their ability to ameliorate cardiac characteristics. Cumulatively, the results clearly suggests that supplementation of EJLE promotes cardio-protective effects through amelioration of cardiac hypertrophy in vitro and in vivo.
基金：
Taiwan Department of Health Clinical Trial and
Research Center of Excellence, Grant/Award
Number: MOHW106-TDU-B-212-113004
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区环境科学与生态学
小类|2 区毒理学2 区水资源3 区环境科学
最新[2025]版：
大类|3 区医学
小类|3 区环境科学3 区毒理学3 区水资源
第一作者：
第一作者机构：[1]Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan.
通讯作者：
通讯机构：[1]Graduate Institute of Aging Medicine, China Medical University, Taichung, Taiwan.[2]Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.[10]Department of Clinical Laboratory, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangdong, China.[11]Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.[*1]Graduate Institute of Basic Medical Science, China Medical University and Hospital, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan.
推荐引用方式(GB/T 7714)：
Chiang Jui-Ting,Badrealam Khan Farheen,Shibu Marthandam Asokan,et al.Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats.[J].Environmental toxicology.2018,33(11):1113-1122.doi:10.1002/tox.22589.
APA：
Chiang Jui-Ting,Badrealam Khan Farheen,Shibu Marthandam Asokan,Kuo Chia-Hua,Huang Chih-Yang...&Huang Chih-Yang.(2018).Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats..Environmental toxicology,33,(11)
MLA：
Chiang Jui-Ting,et al."Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats.".Environmental toxicology 33..11(2018):1113-1122
