机构：[1]Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China[2]Laboratory Medical Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou 521021, Guangdong Province, P. R. China[3]Department of Ultrasonography, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China[4]Department of Traditional Chinese Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China[5]Chaozhou Hybribio Limited Corporation, Chaozhou 521021, Guangdong Province, P. R. China
In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem, and the incidence ranged from 0.5 to 4.08% in different Chinese population. The aims of this study are to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Jiangxi province. 2331 unrelated subjects were screened for G6PD deficiency by a fluorescent test. DNA from deficient individuals was analyzed by a gene chip analysis for thirteen common Chinese G6PD mutations. In total, 3.60% (82/2331; 95% CI 2.77-4.27) of the sample were found to be G6PD-deficient. Eight mutations were found from 80 samples. However, mutation(s) for the two remaining samples were unknown. The most common mutations were G6PD Canton (1376 G>T) and G6PD Kaiping (1388 G>A), and the following mutations were 1311 polymorphism (1311 C>T), G6PD Gaohe (95 A>G), G6PD Chinese-5 (1024 C>T), G6PD Maewo (1360 C>T), Shunde (592 C>T), G6PD Viangchan (871 G>A) and Chinese-3 (493 A>G). This is the first report of G6PD deficiency among Chinese Hakka population in Jiangxi province.
基金：
National Natural
Science Foundation of China
(contract/grant number 8136-
0265 to Tian-Yu Zhong) and
Science and Technology Projects
of Jiangxi EducationalCommittee (contract/grant number GJJ13690
to Rong Hu).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
第一作者：
第一作者机构：[1]Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China
通讯作者：
通讯机构：[1]Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. China[*1]Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, 23 Qingnian Road, Ganzhou 341000, Jiangxi Province, P. R. China.
推荐引用方式(GB/T 7714)：
Hu Rong,Lin Min,Ye Jun,et al.Molecular epidemiological investigation of G6PD deficiency by a gene chip among Chinese Hakka of southern Jiangxi province.[J].International journal of clinical and experimental pathology.2015,8(11):15013-8.
APA：
Hu Rong,Lin Min,Ye Jun,Zheng Bao-Ping,Jiang Li-Xia...&Zhong Tian-Yu.(2015).Molecular epidemiological investigation of G6PD deficiency by a gene chip among Chinese Hakka of southern Jiangxi province..International journal of clinical and experimental pathology,8,(11)
MLA：
Hu Rong,et al."Molecular epidemiological investigation of G6PD deficiency by a gene chip among Chinese Hakka of southern Jiangxi province.".International journal of clinical and experimental pathology 8..11(2015):15013-8
