机构：[1]Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China[2]Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China[3]8th Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, PR China
This study aims to investigate the link between TNF-α gene SNPs and patients with extremity chronic osteomyelitis in China.
Our study included 433 subjects, composed of 233 extremity chronic osteomyelitis patients and 200 controls. Six single-nucleotide polymorphisms (rs1799964, rs1800630, rs1799724, rs1800750, rs1800629 and rs361525) in TNF-α gene were detected by the SNaPshot genotyping method.
Significant genotype distribution of rs1799964 was identified between patients and healthy controls (p = 0.045). In addition, statistical difference was found between rs1799964 SNP and the susceptibility to extremity chronic osteomyelitis (p = 0.044).
We reported for the first time that TNF-α gene SNP rs1799964 contributes to the elevated venture of extremity chronic osteomyelitis in China.
基金：
Disclose any financial interests. This study was supported by Guangdong Provincial Science and Technology Plan Projects
(2016B090913004), Scientific Research Start-up Project of Southern Medical University (PY2017N011), President Foundation
of Nanfang Hospital Southern Medical University (2017Z007) and National Natural Science Foundation of China (NSFC, Grant
NO.81601911).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区药学
第一作者：
第一作者机构：[1]Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
通讯作者：
通讯机构：[1]Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, PR China[2]Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China
推荐引用方式(GB/T 7714)：
Yilong Hou,Lang Bai,Nan Jiang,et al.Screening of TNF-α gene polymorphisms in patients with extremity chronic osteomyelitis in China.[J].Personalized medicine.2018,15(5):395-401.doi:10.2217/pme-2018-0017.
APA：
Yilong Hou,Lang Bai,Nan Jiang,Zilong Yao,Li Xue&Bin Yu.(2018).Screening of TNF-α gene polymorphisms in patients with extremity chronic osteomyelitis in China..Personalized medicine,15,(5)
MLA：
Yilong Hou,et al."Screening of TNF-α gene polymorphisms in patients with extremity chronic osteomyelitis in China.".Personalized medicine 15..5(2018):395-401
