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Activation of GPER suppresses the malignancy of osteosarcoma cells via down regulation of IL-6 and IL-8.

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机构： [1]Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Yongping Road No100, Zhengzhou City, Henan Province, 450016, China [2]The Third Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Guangzhou City, Guangdong Province, 510405, China [3]Southern Medical University, Guangzhou City, Guangdong Province, 510515, China

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关键词： GPER Migration IL-6 IL-8 Osteosarcoma p65

摘要：

Estrogenic signals can regulate the progression of osteosarcoma (OS) via classic estrogen receptor α/β (ERα/β). G protein-coupled estrogen receptor (GPER) can mediate the non-genomic effects of estrogen and regulate the progression of various cancers. Our present study revealed that the expression of GPER in OS cells and tissues was lower than that in their corresponding controls. Activation of GPER via its specific agonist G-1 can decrease the proliferation, migration, and invasion of OS cells. By screening the expression of cytokines involved in the progression of OS, we found that activation of GPER can inhibit the expression of interleukin-6 (IL-6) and IL-8 in OS cells. Recombinant IL-6 (rIL-6) or rIL-8 can attenuate G-1 suppressed migration of OS cells. Mechanically, activation of GPER can rapidly decease the phosphorylation and nuclear translocation of NF-κB in OS cells. While over expression of p65 significantly attenuated G-1 induced down regulation of IL-6/IL-8. Further, G-1 can decrease the activation of p38-MAPK, which can further shorten the half-life of IL-8 mRNA. Collectively, we revealed that GPER can suppress the migration and invasion of OS cells via inhibition of IL-6 and IL-8. It suggested that GPER might be a potential therapy target for OS treatment. Copyright © 2018 Elsevier Inc. All rights reserved.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 3 区生物物理

最新[2025]版：

大类 | 3 区生物学

小类 | 2 区生物物理 3 区生化与分子生物学

第一作者：

第一作者机构： [1]Department of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Yongping Road No100, Zhengzhou City, Henan Province, 450016, China

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通讯机构： [3]Southern Medical University, Guangzhou City, Guangdong Province, 510515, China [*1]Southern Medical University, No. 1023-1063 Sha Tai Nan Road, Baiyun District, Guangzhou, Guangdong Province, 510515, China

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