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Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.

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收录情况： ◇ SCIE

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机构： [1]Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA. [2]Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [3]Department of Radiology, Futian Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China. [4]Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA. [5]Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [6]F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

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关键词： glioma IDH CEST amide proton transfer imaging weighted imaging biomarker

摘要：

To assess the amide proton transfer-weighted (APTw) MRI features of isocitrate dehydrogenase (IDH)-wildtype and IDH-mutant grade II gliomas and to test the hypothesis that the APTw signal is a surrogate imaging marker for identifying IDH mutation status preoperatively. Twenty-seven patients with pathologically confirmed low-grade glioma, who were previously scanned at 3T, were retrospectively analyzed. The Mann-Whitney test was used to evaluate relationships between APTw intensities for IDH-mutant and IDH-wildtype groups, and receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance of APTw. Based on histopathology and molecular analysis, seven cases were diagnosed as IDH-wildtype grade II gliomas and 20 cases as IDH-mutant grade II gliomas. The maximum and minimum APTw values, based on multiple regions of interest, as well as the whole-tumor histogram-based mean and 50th percentile APTw values, were significantly higher in the IDH-wildtype gliomas than in the IDH-mutant groups. This corresponded to the areas under the ROC curves of 0.89, 0.76, 0.75, and 0.75, respectively, for the prediction of the IDH mutation status. IDH-wildtype lesions typically were associated with relatively high APTw signal intensities as compared with IDH-mutant lesions. The APTw signal could be a valuable imaging biomarker by which to identify IDH1 mutation status in grade II gliomas. Magn Reson Med 78:1100-1109, 2017. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

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出版当年[2016]版：

大类 | 2 区

医学

小类 | 2 区核医学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区核医学

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出版当年[2015]版：

Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2023]版：

Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 3 最新[2023版] 3.3 最新五年平均 3.782 出版当年[2015版] 3.899 出版当年五年平均 3.571 出版前一年[2014版] 3.924 出版后一年[2016版]

第一作者：

第一作者机构： [1]Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA. [2]Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [3]Department of Radiology, Futian Traditional Chinese Medicine Hospital, Shenzhen, Guangdong, China.

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通讯作者：

通讯机构： [1]Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA. [6]F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA. [*1]Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Park 336, Baltimore, MD 21287,USA.

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Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI.

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